Medicine Information

Renova

Name: Renova
Brand: Renova

Oral Suspension120 mg/5 mLAntibiotics (3rd Generation Cephalosporins)ATC: J01DD08

Generic Name

Cefixime

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
renova 120 mg suspension	৳ 35.00	N/A

Description

Overview of the medicine

Renova 120 mg Suspension contains Cefixime, which is a third-generation cephalosporin antibiotic used to treat various bacterial infections. It works by stopping the growth of bacteria and is effective against a wide range of bacteria.

Uses & Indications

Uncomplicated Urinary Tract Infections (UTIs)

Otitis Media (middle ear infection)

Pharyngitis and Tonsillitis (sore throat and tonsil infection)

Acute Exacerbations of Chronic Bronchitis

Uncomplicated Gonorrhea

Acute Sinusitis

Dosage

Adults

Adults and children over 10 years or weighing over 50 kg: 400 mg once daily or 200 mg every 12 hours. For suspension, dosage should be calculated based on individual need by physician.

Elderly

No specific dose adjustment is required in elderly patients with normal renal function. Dose adjustment is needed in renal impairment.

Renal_impairment

For creatinine clearance less than 20 mL/min, the dose should be halved (e.g., 200 mg once daily or 100 mg every 12 hours).

How to Take

Administer Renova suspension orally, with or without food. Shake the bottle well before each use to ensure uniform dosage. Use the provided measuring spoon or cup for accurate dosing.

Mechanism of Action

Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved 2-6 hours after oral administration.

Excretion

Approximately 50% of the absorbed dose is excreted unchanged in the urine within 24 hours. The rest is excreted via biliary-fecal route.

Half life

The average plasma half-life in healthy individuals is 3-4 hours.

Absorption

Approximately 40-50% orally absorbed. Absorption may be slightly delayed by food but the total amount absorbed remains unchanged.

Metabolism

Cefixime is not significantly metabolized in the liver.

Side Effects

Contraindications

Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.

Drug Interactions

Nefopam

May increase the risk of CNS adverse effects.

Carbamazepine

Concomitant use with Cefixime may result in increased carbamazepine plasma levels. Monitoring of carbamazepine levels may be considered.

Warfarin and other anticoagulants

Concurrent administration may increase prothrombin time and INR, potentially leading to bleeding episodes. Close monitoring of coagulation parameters is advised.

Storage

Store the dry powder below 30°C, protected from light and moisture. Keep out of reach of children. After reconstitution, store the suspension in the refrigerator (2-8°C) and discard any unused portion after the specified period.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Supportive care, including maintenance of fluid and electrolyte balance, is generally adequate.

Pregnancy & Lactation

Pregnancy Category B. Animal reproduction studies have not demonstrated a fetal risk, but there are no adequate and well-controlled studies in pregnant women. Use in pregnancy only if clearly needed. Cefixime is excreted in small amounts in human milk; caution should be exercised when administered to a nursing woman.

Side Effects

Contraindications

Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.

Drug Interactions

Nefopam

May increase the risk of CNS adverse effects.

Carbamazepine

Concomitant use with Cefixime may result in increased carbamazepine plasma levels. Monitoring of carbamazepine levels may be considered.

Warfarin and other anticoagulants

Concurrent administration may increase prothrombin time and INR, potentially leading to bleeding episodes. Close monitoring of coagulation parameters is advised.

Storage

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 mL bottle (when reconstituted)50 mL bottle (when reconstituted)

Shelf Life

Unreconstituted powder: 24-36 months. Reconstituted suspension: 7-14 days when stored in a refrigerator (2-8°C).

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA

Patent Status

Patent expired for Cefixime

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating a wide range of bacterial infections in both adult and pediatric populations. Studies have compared its effectiveness against other antibiotics and its pharmacokinetic profile.

Lab Monitoring

Renal function tests (e.g., serum creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy.
Liver function tests (e.g., ALT, AST) if hepatotoxicity is suspected, although rare.

Doctor Notes

Always consider local epidemiological data and susceptibility patterns when prescribing Cefixime.
Adjust dosage for patients with significant renal impairment.
Counsel patients on the importance of completing the full course to minimize resistance development.

Patient Guidelines

Complete the entire prescribed course of Renova suspension, even if symptoms improve earlier, to prevent recurrence and development of antibiotic resistance.
Shake the suspension bottle well before each use.
Use the provided measuring device for accurate dosing.
Report any severe or persistent side effects to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Renova suspension may cause dizziness in some patients. If you experience dizziness, avoid driving or operating machinery until you know how the medicine affects you.