Renova
Generic Name
Levofloxacin
Manufacturer
Various manufacturers (e.g., Square Pharmaceuticals Ltd., Beximco Pharmaceuticals Ltd.)
Country
Globally manufactured
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| renova 500 mg tablet | ৳ 1.20 | ৳ 12.00 |
Description
Overview of the medicine
Levofloxacin is a synthetic broad-spectrum antibacterial agent of the fluoroquinolone class, active against a wide range of gram-positive and gram-negative bacteria. It is used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Typically 500 mg once daily for 7-14 days depending on the infection. For specific indications, 250 mg or 750 mg once daily may be prescribed.
Elderly
No dose adjustment generally required unless renal function is impaired. Monitor renal function.
Renal_impairment
Dose adjustment required based on creatinine clearance (CrCl). For CrCl 20-49 mL/min: 250 mg every 24 hours (or 500 mg initial, then 250 mg q24h). For CrCl 10-19 mL/min: 250 mg every 48 hours (or 500 mg initial, then 250 mg q48h).
How to Take
Oral administration. May be taken with or without food. Ensure adequate hydration. Do not take with antacids containing magnesium or aluminum, sucralfate, metal cations (e.g., iron, zinc), or multivitamins containing iron or zinc. Separate administration by at least 2 hours.
Mechanism of Action
Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours of administration.
Excretion
Primarily excreted unchanged in the urine (approximately 87%) by glomerular filtration and tubular secretion.
Half life
Approximately 6-8 hours.
Absorption
Rapid and complete absorption after oral administration; peak plasma concentrations reached within 1-2 hours.
Metabolism
Minimally metabolized; less than 5% of a dose is metabolized.
Side Effects
Contraindications
- •Hypersensitivity to levofloxacin or other quinolones
- •History of tendinitis or tendon rupture associated with fluoroquinolone use
- •Epilepsy or other seizure disorders
- •Children and adolescents (under 18 years old)
Drug Interactions
NSAIDs
Increased risk of CNS stimulation and convulsions.
Warfarin
Potentiation of anticoagulant effect, leading to increased bleeding risk.
Corticosteroids
Increased risk of tendon rupture.
Insulin/Oral Hypoglycemic Agents
Risk of blood glucose disturbances (hypo- or hyperglycemia).
Antacids (Mg/Al), Sucralfate, Metal Cations (Fe, Zn)
Reduced absorption of levofloxacin; separate administration by at least 2 hours.
Antiarrhythmics (e.g., Quinidine, Procainamide, Amiodarone)
Increased risk of QT prolongation and cardiac arrhythmias.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include CNS effects (confusion, dizziness, convulsions, tremors), QT prolongation, and renal impairment. Treatment is symptomatic and supportive; hemodialysis is not effective. Maintain adequate hydration.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk and may harm the infant's developing cartilage.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date. Refer to the specific product packaging for exact details.
Availability
Available in pharmacies worldwide
Approval Status
Approved by regulatory bodies like FDA and DGDA (or equivalent)
Patent Status
Patent expired, generic versions available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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