Medicine Information

Renova

Name: Renova
Brand: Renova

Suppository60 mgNon-steroidal Anti-inflammatory Drug (NSAID)ATC: M01AB05

Generic Name

Diclofenac Sodium 60 mg Suppository

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
renova 60 mg suppository	৳ 3.51	N/A

Description

Overview of the medicine

Renova 60 mg Suppository contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and inflammation.

Uses & Indications

Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis

Acute musculoskeletal disorders

Post-operative pain and inflammation

Dysmenorrhea

Fever associated with inflammation

Dosage

Adults

Typically 60-100 mg daily in divided doses, rectally. Maximum 150 mg per day.

Elderly

Lower doses should be considered, with careful monitoring due to increased risk of side effects.

Renal_impairment

Use with caution; dose adjustment may be necessary in severe impairment. Start with the lowest effective dose.

How to Take

For rectal use only. The suppository should be inserted gently into the rectum. It is generally recommended to lie down for a few minutes after insertion.

Mechanism of Action

Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to a reduction in prostaglandin synthesis, which are mediators of pain and inflammation.

Pharmacokinetics

Onset

Within 30-60 minutes.

Excretion

Approximately 60% excreted in urine as metabolites and less than 1% as unchanged drug; 35% excreted in bile/feces.

Half life

Plasma elimination half-life is 1-2 hours.

Absorption

Rapid and complete absorption from the rectal mucosa.

Metabolism

Extensively metabolized in the liver, primarily by hydroxylation and glucuronidation (CYP2C9).

Side Effects

Contraindications

Hypersensitivity to diclofenac, aspirin, or other NSAIDs.
Active gastrointestinal ulceration, bleeding, or perforation.
Severe heart failure (NYHA Class IV).
Severe renal or hepatic impairment.
Third trimester of pregnancy.
Proctitis or recent rectal bleeding.

Drug Interactions

SSRIs

Increased risk of gastrointestinal bleeding.

Corticosteroids

Increased risk of gastrointestinal ulceration or bleeding.

Lithium, Digoxin, Methotrexate

Increased plasma levels of these drugs.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Diuretics, ACE inhibitors, ARBs

Reduced efficacy of these drugs and increased risk of renal impairment.

Storage

Store in a cool, dry place, below 30°C. Protect from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management is primarily supportive and symptomatic; no specific antidote.

Pregnancy & Lactation

Avoid in the third trimester of pregnancy. Use with caution and only if clearly needed in the first and second trimesters. Diclofenac is excreted in breast milk; use with caution during lactation.

Side Effects

Contraindications

Hypersensitivity to diclofenac, aspirin, or other NSAIDs.
Active gastrointestinal ulceration, bleeding, or perforation.
Severe heart failure (NYHA Class IV).
Severe renal or hepatic impairment.
Third trimester of pregnancy.
Proctitis or recent rectal bleeding.

Drug Interactions

SSRIs

Increased risk of gastrointestinal bleeding.

Corticosteroids

Increased risk of gastrointestinal ulceration or bleeding.

Lithium, Digoxin, Methotrexate

Increased plasma levels of these drugs.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Diuretics, ACE inhibitors, ARBs

Reduced efficacy of these drugs and increased risk of renal impairment.

Storage

Store in a cool, dry place, below 30°C. Protect from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management is primarily supportive and symptomatic; no specific antidote.

Pregnancy & Lactation

Avoid in the third trimester of pregnancy. Use with caution and only if clearly needed in the first and second trimesters. Diclofenac is excreted in breast milk; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Pack of 5 suppositoriesPack of 10 suppositories

Shelf Life

Typically 24 to 36 months from the date of manufacture.

Availability

Available in pharmacies

Approval Status

Approved (General use for Diclofenac)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Diclofenac has undergone extensive clinical trials supporting its efficacy and safety for various indications.

Lab Monitoring

Complete blood count (CBC)
Liver function tests (LFTs)
Kidney function tests (serum creatinine, BUN)
Stool occult blood test for long-term use

Doctor Notes

Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Monitor for signs and symptoms of GI bleeding, cardiovascular events, and renal toxicity, especially in high-risk patients.
Caution advised in patients with pre-existing cardiovascular disease, hypertension, or fluid retention.

Patient Guidelines

Use the lowest effective dose for the shortest possible duration to minimize risks.
Avoid alcohol while taking this medicine.
Report any unusual bleeding, persistent stomach pain, or black stools to your doctor immediately.
Do not lie down immediately after inserting the suppository.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.