Renova
Generic Name
Diclofenac Sodium 60 mg Suppository
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| renova 60 mg suppository | ৳ 3.51 | N/A |
Description
Overview of the medicine
Renova 60 mg Suppository contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and inflammation.
Uses & Indications
Dosage
Adults
Typically 60-100 mg daily in divided doses, rectally. Maximum 150 mg per day.
Elderly
Lower doses should be considered, with careful monitoring due to increased risk of side effects.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe impairment. Start with the lowest effective dose.
How to Take
For rectal use only. The suppository should be inserted gently into the rectum. It is generally recommended to lie down for a few minutes after insertion.
Mechanism of Action
Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to a reduction in prostaglandin synthesis, which are mediators of pain and inflammation.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Approximately 60% excreted in urine as metabolites and less than 1% as unchanged drug; 35% excreted in bile/feces.
Half life
Plasma elimination half-life is 1-2 hours.
Absorption
Rapid and complete absorption from the rectal mucosa.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation and glucuronidation (CYP2C9).
Side Effects
Contraindications
- •Hypersensitivity to diclofenac, aspirin, or other NSAIDs.
- •Active gastrointestinal ulceration, bleeding, or perforation.
- •Severe heart failure (NYHA Class IV).
- •Severe renal or hepatic impairment.
- •Third trimester of pregnancy.
- •Proctitis or recent rectal bleeding.
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Lithium, Digoxin, Methotrexate
Increased plasma levels of these drugs.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics, ACE inhibitors, ARBs
Reduced efficacy of these drugs and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management is primarily supportive and symptomatic; no specific antidote.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy. Use with caution and only if clearly needed in the first and second trimesters. Diclofenac is excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies
Approval Status
Approved (General use for Diclofenac)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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