For rectal administration only. Wash hands before and after use. Unwrap the suppository and insert it gently into the rectum, pointed end first.

Renova 125 mg Suppository works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever, so their inhibition leads to analgesic, anti-inflammatory, and antipyretic effects.

• •Hypersensitivity to the active substance or excipients
• •Active gastrointestinal bleeding or peptic ulcer
• •Severe renal or hepatic impairment
• •Last trimester of pregnancy
• •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs

Store in a cool, dry place, below 25°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.

Symptoms may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. In severe cases, acute renal failure, hepatic dysfunction, hypotension, respiratory depression, and coma may occur. Management involves symptomatic and supportive care; gastric lavage and activated charcoal are generally not applicable for rectal overdose.

Not recommended during the third trimester of pregnancy due to potential adverse effects on fetal cardiovascular system. Use during first and second trimesters and lactation only if clearly necessary and under strict medical supervision. Avoid in breastfeeding mothers unless benefits outweigh risks.