Renova
Generic Name
Renova-125-mg Suppository
Manufacturer
Fictional Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
renova 125 mg suppository | ৳ 4.02 | N/A |
Description
Overview of the medicine
Renova 125 mg Suppository is a non-steroidal anti-inflammatory drug (NSAID) used for the symptomatic relief of mild to moderate pain, fever, and inflammation, particularly when oral administration is not feasible.
Uses & Indications
Dosage
Adults
One 125 mg suppository 2-3 times daily, or as directed by physician.
Elderly
Lower doses may be required; caution advised due to increased risk of adverse effects.
Renal_impairment
Use with caution; dose reduction may be necessary depending on the degree of impairment.
How to Take
For rectal administration only. Wash hands before and after use. Unwrap the suppository and insert it gently into the rectum, pointed end first.
Mechanism of Action
Renova 125 mg Suppository works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever, so their inhibition leads to analgesic, anti-inflammatory, and antipyretic effects.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly excreted in urine as metabolites and unconjugated drug.
Half life
Approximately 2-4 hours
Absorption
Rapidly absorbed from the rectal mucosa; peak plasma concentrations achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver via glucuronidation and hydroxylation.
Side Effects
Contraindications
- Hypersensitivity to the active substance or excipients
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Last trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma levels of lithium.
Methotrexate
Increased toxicity of methotrexate.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics and Antihypertensives
Reduced effectiveness of these medications.
Storage
Store in a cool, dry place, below 25°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. In severe cases, acute renal failure, hepatic dysfunction, hypotension, respiratory depression, and coma may occur. Management involves symptomatic and supportive care; gastric lavage and activated charcoal are generally not applicable for rectal overdose.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential adverse effects on fetal cardiovascular system. Use during first and second trimesters and lactation only if clearly necessary and under strict medical supervision. Avoid in breastfeeding mothers unless benefits outweigh risks.
Side Effects
Contraindications
- Hypersensitivity to the active substance or excipients
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Last trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma levels of lithium.
Methotrexate
Increased toxicity of methotrexate.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics and Antihypertensives
Reduced effectiveness of these medications.
Storage
Store in a cool, dry place, below 25°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. In severe cases, acute renal failure, hepatic dysfunction, hypotension, respiratory depression, and coma may occur. Management involves symptomatic and supportive care; gastric lavage and activated charcoal are generally not applicable for rectal overdose.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential adverse effects on fetal cardiovascular system. Use during first and second trimesters and lactation only if clearly necessary and under strict medical supervision. Avoid in breastfeeding mothers unless benefits outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Clinical trials for this specific hypothetical formulation are not available. General NSAID efficacy and safety data are well-established.
Lab Monitoring
- Complete Blood Count (CBC) (for long-term use)
- Renal function tests (e.g., creatinine, BUN)
- Liver function tests (e.g., ALT, AST)
- Stool occult blood test (if GI symptoms occur)
Doctor Notes
- Monitor patients for signs of GI bleeding or cardiovascular adverse events, especially with long-term use.
- Assess renal and hepatic function periodically in patients receiving chronic therapy.
- Caution in patients with a history of asthma or allergies.
Patient Guidelines
- Use exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual bleeding, persistent stomach pain, or black stools to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid alcohol consumption while using this medicine.
- Maintain adequate hydration.
- Inform your doctor about all other medications and supplements you are taking.
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Global Brand Names
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