Medicine Information

Renova

Name: Renova
Brand: Renova

Syrup120 mg per 5 mLAnalgesic, AntipyreticATC: N02BE01

Generic Name

Paracetamol (Acetaminophen) 120 mg/5 ml Syrup

Manufacturer

Hypothetical Pharma Co.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
renova 120 mg syrup	৳ 35.00	N/A

Description

Overview of the medicine

Renova 120 mg Syrup contains Paracetamol, which is used to relieve mild to moderate pain and to reduce fever. It is suitable for children and adults who prefer liquid formulations.

Uses & Indications

Relief of mild to moderate pain (e.g., headache, muscle aches, toothache, menstrual pain)

Reduction of fever (e.g., associated with colds, flu, vaccinations)

Adjuvant in symptomatic relief of cold and flu

Dosage

Adults

10-20 mL (240-480 mg) every 4-6 hours as needed, not to exceed 80 mL (1920 mg) in 24 hours.

Elderly

Similar to adult dosage, but caution with hepatic/renal impairment. Consult physician.

Renal_impairment

Dosage interval may need to be extended (e.g., 6-8 hours) depending on creatinine clearance. Consult physician.

How to Take

Administer orally. Shake the bottle well before use. Use a measuring cup or spoon for accurate dosing.

Mechanism of Action

Paracetamol's exact mechanism is not fully understood, but it is believed to act primarily by inhibiting prostaglandin synthesis in the central nervous system (CNS), leading to its analgesic and antipyretic effects. It has minimal anti-inflammatory effects.

Pharmacokinetics

Onset

30-60 minutes for analgesic/antipyretic effect.

Excretion

Mainly excreted in urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.

Half life

1-4 hours (typically 2-3 hours) in adults with normal hepatic function.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract; peak plasma concentrations occur within 30-60 minutes.

Metabolism

Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small portion is metabolized by cytochrome P450 enzymes to a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by conjugation with glutathione.

Side Effects

Contraindications

Known hypersensitivity to Paracetamol or any other component of the syrup
Severe hepatic impairment or active liver disease

Drug Interactions

Alcohol

Chronic alcohol consumption may increase the risk of hepatotoxicity with paracetamol.

Warfarin

May enhance the anticoagulant effect of warfarin, increasing bleeding risk with prolonged use of high doses of paracetamol.

Chloramphenicol

May increase chloramphenicol levels.

Certain anticonvulsants (e.g., Phenytoin, Carbamazepine)

May increase paracetamol metabolism, potentially reducing its efficacy and increasing the risk of hepatotoxicity.

Storage

Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Overdose can cause severe, potentially fatal hepatic necrosis. Symptoms may include nausea, vomiting, abdominal pain, and diaphoresis, which may appear 24-48 hours after ingestion. Management involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.

Pregnancy & Lactation

Paracetamol is generally considered safe for use during pregnancy and breastfeeding at recommended doses. However, it should be used with caution and under medical supervision.

Side Effects

Contraindications

Known hypersensitivity to Paracetamol or any other component of the syrup
Severe hepatic impairment or active liver disease

Drug Interactions

Alcohol

Chronic alcohol consumption may increase the risk of hepatotoxicity with paracetamol.

Warfarin

May enhance the anticoagulant effect of warfarin, increasing bleeding risk with prolonged use of high doses of paracetamol.

Chloramphenicol

May increase chloramphenicol levels.

Certain anticonvulsants (e.g., Phenytoin, Carbamazepine)

May increase paracetamol metabolism, potentially reducing its efficacy and increasing the risk of hepatotoxicity.

Storage

Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Paracetamol is generally considered safe for use during pregnancy and breastfeeding at recommended doses. However, it should be used with caution and under medical supervision.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 mL bottle100 mL bottle

Shelf Life

Typically 2-3 years from manufacturing date, check specific product packaging.

Availability

Pharmacies, drugstores

Approval Status

Approved (Widely used and accepted)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Paracetamol has been extensively studied and is a well-established medication with a vast body of clinical evidence supporting its efficacy and safety profile for pain and fever management.

Lab Monitoring

Liver function tests (ALT, AST) in cases of suspected overdose or prolonged high-dose therapy
Prothrombin time (PT) / INR if taking warfarin concomitantly

Doctor Notes

Emphasize the importance of accurate dosing, especially in pediatric patients, to prevent accidental overdose.
Counsel patients on the maximum daily dose and the risks associated with exceeding it.
Advise against concomitant use of other paracetamol-containing preparations.

Patient Guidelines

Do not exceed the recommended dose to avoid serious liver damage.
Do not use with other paracetamol-containing products.
If pain or fever persists for more than a few days, consult a doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Generally, paracetamol does not affect the ability to drive or operate machinery. However, if you experience dizziness or drowsiness, avoid such activities.