Rovantin
Generic Name
Atorvastatin Calcium
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rovantin 100 mg tablet | ৳ 14.05 | ৳ 140.50 |
| rovantin 200 mg tablet | ৳ 25.16 | ৳ 251.60 |
| rovantin 40 mg suspension | ৳ 98.66 | N/A |
| rovantin 20 mg pediatric drop | ৳ 60.42 | N/A |
Description
Overview of the medicine
Rovantin (Atorvastatin) is a statin medication used to lower elevated cholesterol levels (LDL-C, total cholesterol, triglycerides) and increase HDL-C in patients with hyperlipidemia. It is also used to reduce the risk of cardiovascular events such as heart attack and stroke.
Uses & Indications
Dosage
Adults
Initial dose: 10 mg or 20 mg once daily. Max dose: 80 mg once daily.
Elderly
No dosage adjustment is generally required.
Renal_impairment
No dosage adjustment required.
How to Take
Oral administration, once daily, with or without food, at any time of day.
Mechanism of Action
Atorvastatin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the early rate-limiting step in cholesterol biosynthesis. This leads to a decrease in hepatic cholesterol synthesis and an increase in LDL receptors on liver cells, enhancing LDL-C uptake and catabolism.
Pharmacokinetics
Onset
Lipid-lowering effects seen within 2 weeks, maximal by 4 weeks.
Excretion
Primarily biliary excretion after hepatic and/or extrahepatic metabolism. Less than 2% is recovered in urine.
Half life
Parent drug half-life: ~14 hours. Active metabolites contribute to 20-30 hours of HMG-CoA reductase inhibitory activity.
Absorption
Rapidly absorbed. Peak plasma concentrations in 1-2 hours. Absolute bioavailability approx. 14%.
Metabolism
Extensive hepatic metabolism via CYP3A4 to active ortho- and parahydroxylated metabolites and various beta-oxidation products.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Hypersensitivity to Atorvastatin or any component of the formulation
Drug Interactions
0
CYP3A4 Inhibitors (e.g., Itraconazole, Ketoconazole, Erythromycin, Clarithromycin, Ciclosporin, Protease inhibitors) can increase Atorvastatin levels, increasing risk of myopathy.
1
Fibrates (e.g., Gemfibrozil) and Niacin can increase the risk of myopathy/rhabdomyolysis when co-administered with Atorvastatin.
2
Colchicine: Cases of myopathy, including rhabdomyolysis, have been reported with coadministration of colchicine and atorvastatin.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for atorvastatin overdose. In the event of an overdose, the patient should be treated symptomatically, and supportive measures instituted as required. Liver function tests and CK levels should be monitored.
Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy and lactation due to the potential for harm to the fetus or breastfed infant. Women of childbearing potential should use effective contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent expired (generics available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Atorvastatin in reducing lipid levels and cardiovascular risk across various patient populations, including the ASCOT-LLA, MIRACL, and TNT studies.
Lab Monitoring
- Liver function tests (ALT, AST) before treatment and periodically thereafter
- Lipid panel (total cholesterol, LDL-C, HDL-C, triglycerides) to monitor efficacy
- Creatine kinase (CK) levels if muscle pain, tenderness, or weakness occur
Doctor Notes
- Counsel patients on the importance of diet and exercise in conjunction with Atorvastatin therapy.
- Monitor liver function tests (ALT, AST) at baseline and as clinically indicated.
- Advise patients to report any muscle symptoms promptly.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor, usually once daily.
- Do not stop taking Atorvastatin without consulting your doctor.
- Report any unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or dark urine, to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Atorvastatin has no or negligible influence on the ability to drive and use machines. However, individual responses to drugs vary, so patients should be aware of how they react before driving or operating machinery.
Lifestyle Advice
- Maintain a cholesterol-lowering diet, low in saturated fat and cholesterol.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and limit alcohol consumption.
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Global Brand Names
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