Sefurox
Generic Name
Cefuroxime Axetil
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sefurox 500 mg tablet | ৳ 45.31 | ৳ 181.24 |
Description
Overview of the medicine
Cefuroxime is a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
250 mg to 500 mg twice daily, depending on the severity and type of infection. For this 500 mg tablet, typically 500 mg twice daily.
Elderly
Similar to adult dosage, but caution and dosage adjustment may be required in elderly patients with reduced renal function.
Renal_impairment
Dosage must be reduced in patients with significant renal impairment. Refer to specific guidelines based on creatinine clearance.
How to Take
Take orally, preferably with food to enhance absorption. Do not crush or chew the tablet.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
Pharmacokinetics
Onset
Peak plasma concentrations achieved within 2-3 hours.
Excretion
Primarily excreted by the kidneys via glomerular filtration and tubular secretion.
Half life
Approximately 1.2-1.6 hours.
Absorption
Well absorbed after oral administration; bioavailability is enhanced when taken with food (approx. 37-52%).
Metabolism
Not extensively metabolized in the liver; largely excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams)
Drug Interactions
Antacids
May decrease bioavailability if taken concurrently.
Probenecid
May increase cefuroxime concentration and prolong its effect.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; additional birth control methods are advised.
Anticoagulants (e.g., Warfarin)
May enhance anticoagulant effect; INR monitoring is recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include neurological disorders like encephalopathy, convulsions. Management is symptomatic and supportive; hemodialysis may be used to remove the drug from the system.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in small amounts into breast milk, generally considered compatible with breastfeeding, but monitor infant for potential side effects.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams)
Drug Interactions
Antacids
May decrease bioavailability if taken concurrently.
Probenecid
May increase cefuroxime concentration and prolong its effect.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; additional birth control methods are advised.
Anticoagulants (e.g., Warfarin)
May enhance anticoagulant effect; INR monitoring is recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include neurological disorders like encephalopathy, convulsions. Management is symptomatic and supportive; hemodialysis may be used to remove the drug from the system.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in small amounts into breast milk, generally considered compatible with breastfeeding, but monitor infant for potential side effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established its efficacy and safety across various bacterial infections. Ongoing research explores new indications and resistance patterns.
Lab Monitoring
- Renal function tests (especially in patients with renal impairment or on prolonged therapy)
- Complete blood count (CBC) during prolonged therapy
- Liver function tests (if liver enzyme elevation is suspected)
Doctor Notes
- Advise patients to complete the full course of treatment to prevent antibiotic resistance.
- Exercise caution in patients with a history of penicillin allergy, as cross-reactivity may occur.
- Dosage adjustment is crucial for patients with renal impairment.
- Monitor for signs of _Clostridium difficile_-associated diarrhea.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not skip doses or stop taking the medicine prematurely.
- Do not share this medicine with others.
- Inform your doctor about any allergic reactions or severe side effects.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefuroxime may cause dizziness. Patients should be advised to exercise caution when driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Ensure adequate rest to aid recovery.
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