Sonipred
Generic Name
Prednisolone
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sonipred 20 mg tablet | ৳ 6.29 | ৳ 62.90 |
Description
Overview of the medicine
Sonipred 20 mg Tablet contains Prednisolone, a corticosteroid used to treat a wide range of inflammatory and autoimmune conditions, as well as certain cancers and allergic reactions. It works by reducing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on the condition being treated and individual response. Typically ranges from 5 mg to 60 mg daily, often given in divided doses or as a single daily dose, preferably in the morning. A gradual dose tapering is usually required.
Elderly
No specific dose adjustment for elderly patients is usually required, but caution should be exercised due to increased risk of side effects (e.g., osteoporosis, diabetes, hypertension).
Renal_impairment
No specific dose adjustment is generally required for renal impairment, as prednisolone is primarily metabolized in the liver. However, caution is advised in severe cases.
How to Take
Take Sonipred 20 mg Tablet orally, usually once daily with food or milk to minimize gastric irritation. It is often recommended to take the entire daily dose in the morning to mimic the body's natural cortisol rhythm.
Mechanism of Action
Prednisolone is a synthetic glucocorticoid that binds to specific intracellular glucocorticoid receptors. This complex then translocates to the nucleus, where it modulates gene expression, leading to anti-inflammatory and immunosuppressive effects. It inhibits the release of inflammatory mediators and suppresses the function of various immune cells.
Pharmacokinetics
Onset
Onset of action is variable, typically within hours for anti-inflammatory effects.
Excretion
Mainly excreted in the urine as inactive metabolites and, to a lesser extent, as unchanged drug. Minor excretion occurs via bile.
Half life
Plasma elimination half-life is approximately 2-3 hours; however, its biological half-life is longer (18-36 hours) due to tissue binding and cellular effects.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are usually achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites (e.g., prednisone) and conjugated forms. Metabolism is mediated by CYP3A4.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any components of the formulation
- Live vaccines (during high-dose corticosteroid therapy)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulcers and bleeding.
Antidiabetic agents
May increase blood glucose levels, requiring adjustment of antidiabetic medication.
Anticoagulants (Warfarin)
Effects may be altered; monitor INR closely.
Diuretics (Thiazide or Loop)
Increased potassium loss.
CYP3A4 Inhibitors (e.g., Ketoconazole, Macrolides)
May increase prednisolone levels, increasing risk of side effects.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin, Barbiturates)
May decrease prednisolone levels, reducing its efficacy.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Chronic overdose can lead to Cushingoid features, muscle weakness, and hypertension. Management is primarily symptomatic and supportive; gradual reduction of dose is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any components of the formulation
- Live vaccines (during high-dose corticosteroid therapy)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulcers and bleeding.
Antidiabetic agents
May increase blood glucose levels, requiring adjustment of antidiabetic medication.
Anticoagulants (Warfarin)
Effects may be altered; monitor INR closely.
Diuretics (Thiazide or Loop)
Increased potassium loss.
CYP3A4 Inhibitors (e.g., Ketoconazole, Macrolides)
May increase prednisolone levels, increasing risk of side effects.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin, Barbiturates)
May decrease prednisolone levels, reducing its efficacy.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Chronic overdose can lead to Cushingoid features, muscle weakness, and hypertension. Management is primarily symptomatic and supportive; gradual reduction of dose is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved (General use)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Prednisolone has been extensively studied in numerous clinical trials for its efficacy in various inflammatory, autoimmune, and oncological conditions. It is a well-established and widely used medication.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients)
- Blood pressure
- Electrolytes (e.g., potassium)
- Bone mineral density (for long-term use)
- Ophthalmic exams (for long-term use, to check for cataracts/glaucoma)
Doctor Notes
- Emphasize the importance of not abruptly discontinuing therapy.
- Monitor for signs of infection, blood glucose, blood pressure, and bone health in patients on long-term therapy.
- Consider calcium and vitamin D supplementation for patients at risk of osteoporosis.
Patient Guidelines
- Always take this medicine exactly as prescribed by your doctor.
- Do not stop taking this medicine suddenly without consulting your doctor, as it can lead to serious withdrawal symptoms.
- Take with food or milk to minimize stomach upset.
- Inform your doctor about any existing medical conditions or medications you are taking.
- Report any unusual side effects or signs of infection immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Prednisolone may cause dizziness or visual disturbances in some individuals. If affected, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a balanced diet, potentially low in sodium and high in potassium. Engage in regular, weight-bearing exercise to support bone health. Avoid exposure to people with infections.
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