Sonipred
Generic Name
Prednisolone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sonipred 5 mg tablet | ৳ 1.73 | ৳ 69.20 |
Description
Overview of the medicine
Prednisolone is a synthetic corticosteroid used for its potent anti-inflammatory and immunosuppressive properties. It is prescribed for a wide range of inflammatory and autoimmune conditions.
Uses & Indications
Dosage
Adults
Initial dose typically 5-60 mg daily, adjusted according to the specific condition, severity, and patient response. It may be given as a single dose or in divided doses.
Elderly
Lower doses may be sufficient, and careful monitoring for side effects is advised due to increased susceptibility in elderly patients. Start with the lowest effective dose.
Renal_impairment
No specific dose adjustment is usually required in renal impairment, but caution is advised. Monitor for signs of fluid retention.
How to Take
Sonipred tablet should be taken orally, preferably with food or milk to minimize gastric irritation. Take exactly as prescribed by your doctor.
Mechanism of Action
Prednisolone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene expression. This leads to the inhibition of inflammatory mediators and suppression of immune responses.
Pharmacokinetics
Onset
Varies depending on the condition being treated, typically within hours to days for noticeable effects.
Excretion
Mainly excreted in the urine as inactive metabolites and conjugates. A small amount is excreted unchanged.
Half life
Plasma half-life is approximately 2-4 hours, while the biological half-life (reflecting duration of action) is 18-36 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites, including 20-hydroxy prednisolone, and conjugates.
Side Effects
Contraindications
- Systemic fungal infections (unless anti-fungal treatment is also given)
- Known hypersensitivity to prednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy
- Acute untreated infections (e.g., viral, bacterial, parasitic)
Drug Interactions
Cyclosporine
Increased plasma levels of both prednisolone and cyclosporine, potentially increasing toxicity.
Antidiabetic agents
Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication.
Anticoagulants (e.g., warfarin)
May alter anticoagulant effects; monitor INR.
Rifampicin, Phenytoin, Barbiturates
May reduce corticosteroid efficacy by increasing its metabolism.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics (especially thiazide or loop diuretics)
Increased risk of potassium depletion.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of acute overdose are rare but may include fluid retention, hypertension, and mood disturbances. Chronic overdose can lead to Cushingoid features. Treatment is supportive and symptomatic; there is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution is advised during breastfeeding, and the infant should be monitored for adverse effects.
Side Effects
Contraindications
- Systemic fungal infections (unless anti-fungal treatment is also given)
- Known hypersensitivity to prednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy
- Acute untreated infections (e.g., viral, bacterial, parasitic)
Drug Interactions
Cyclosporine
Increased plasma levels of both prednisolone and cyclosporine, potentially increasing toxicity.
Antidiabetic agents
Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication.
Anticoagulants (e.g., warfarin)
May alter anticoagulant effects; monitor INR.
Rifampicin, Phenytoin, Barbiturates
May reduce corticosteroid efficacy by increasing its metabolism.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics (especially thiazide or loop diuretics)
Increased risk of potassium depletion.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of acute overdose are rare but may include fluid retention, hypertension, and mood disturbances. Chronic overdose can lead to Cushingoid features. Treatment is supportive and symptomatic; there is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution is advised during breastfeeding, and the infant should be monitored for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Prednisolone has been extensively studied and used clinically for decades. Numerous clinical trials support its efficacy in various inflammatory and autoimmune conditions. Ongoing research focuses on optimizing dosing, reducing side effects, and exploring new applications.
Lab Monitoring
- Blood glucose levels (especially in diabetic or predisposed patients)
- Electrolyte levels (particularly potassium)
- Blood pressure
- Bone density scans (for long-term therapy)
- Ophthalmic examinations (for long-term therapy to detect cataracts/glaucoma)
Doctor Notes
- Counsel patients thoroughly on the importance of gradual tapering and the risks of abrupt discontinuation.
- Monitor blood pressure, blood glucose, and electrolyte levels regularly, especially during prolonged therapy.
- Consider calcium and vitamin D supplementation for patients on long-term corticosteroid therapy to mitigate osteoporosis risk.
- Advise patients to report any signs of infection promptly due to immunosuppressive effects.
Patient Guidelines
- Do not stop taking this medicine abruptly, especially after prolonged use, as it may lead to severe withdrawal symptoms. Always follow your doctor's instructions for tapering the dose.
- Report any unusual symptoms or side effects to your doctor immediately.
- Take Sonipred with food or milk to reduce stomach upset.
- Avoid close contact with people who have infections (like chickenpox, measles) as your immunity might be lowered.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Some patients may experience dizziness or visual disturbances (e.g., blurred vision) while taking prednisolone. If these symptoms occur, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to counteract potential bone thinning (osteoporosis).
- Engage in regular, moderate exercise (if medically permitted) to maintain muscle strength and bone health.
- Monitor blood sugar regularly if you have diabetes or are at risk, as prednisolone can raise blood glucose.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Sonipred Brand
Other medicines available under the same brand name
