Sonipred
Generic Name
Prednisolone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sonipred 5 mg oral solution | ৳ 65.00 | N/A |
Description
Overview of the medicine
Sonipred 5 mg Oral Solution contains Prednisolone, a synthetic corticosteroid. It is primarily used for its anti-inflammatory and immunosuppressive effects in various conditions such as asthma, allergies, arthritis, skin disorders, and autoimmune diseases.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the condition being treated. Typical initial doses range from 5 mg to 60 mg daily, usually divided into 2-4 doses. For severe conditions, higher doses may be used. Tapering is required for long-term use.
Elderly
Use with caution in elderly patients due to increased risk of side effects, especially osteoporosis and fluid retention. Lower doses may be appropriate.
Renal_impairment
No specific dose adjustment is usually required for renal impairment, but caution is advised in severe cases due to potential fluid retention.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal irritation. The solution can be taken directly or mixed with water/juice.
Mechanism of Action
Prednisolone acts by binding to specific glucocorticoid receptors in the cytoplasm, forming a complex that translocates to the cell nucleus. This complex modulates gene expression, leading to the synthesis of anti-inflammatory proteins and inhibition of pro-inflammatory mediators. It also suppresses immune responses by affecting the function of lymphocytes and other immune cells.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within 1-2 hours, with full effects varying based on the condition.
Excretion
Excreted mainly in the urine as inactive metabolites. A small amount is excreted unchanged.
Half life
Plasma half-life is 2-4 hours, but biological half-life is 18-36 hours due to tissue binding.
Absorption
Well absorbed orally, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites, mainly by cytochrome P450 enzymes.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Live vaccines administration in patients receiving immunosuppressive doses
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding and ulceration.
Antidiabetic agents
Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication.
Anticoagulants (e.g., Warfarin)
May alter anticoagulant effects; close monitoring of INR is required.
Phenytoin, Phenobarbital, Rifampicin
May decrease prednisolone efficacy by increasing its metabolism.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased potassium depletion.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is rarely life-threatening. Symptoms may include fluid retention, hypertension, and electrolyte imbalance. Chronic overdose can lead to Cushing's syndrome, hyperglycemia, and increased susceptibility to infection. Management involves supportive care and gradual reduction of the drug.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted into breast milk and may affect infants; caution is advised, and breastfeeding should be avoided with high or prolonged doses.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Live vaccines administration in patients receiving immunosuppressive doses
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding and ulceration.
Antidiabetic agents
Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication.
Anticoagulants (e.g., Warfarin)
May alter anticoagulant effects; close monitoring of INR is required.
Phenytoin, Phenobarbital, Rifampicin
May decrease prednisolone efficacy by increasing its metabolism.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased potassium depletion.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is rarely life-threatening. Symptoms may include fluid retention, hypertension, and electrolyte imbalance. Chronic overdose can lead to Cushing's syndrome, hyperglycemia, and increased susceptibility to infection. Management involves supportive care and gradual reduction of the drug.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted into breast milk and may affect infants; caution is advised, and breastfeeding should be avoided with high or prolonged doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture when stored properly.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Prednisolone, being a well-established corticosteroid, has been extensively studied in numerous clinical trials across various indications. These trials have confirmed its efficacy and safety profile in inflammatory, allergic, and autoimmune conditions.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels (especially potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Adrenal function tests (after withdrawal)
Doctor Notes
- Emphasize the importance of not discontinuing the drug abruptly due to the risk of adrenal crisis.
- Monitor blood pressure, blood glucose, and bone density in patients on long-term therapy.
- Educate patients on potential side effects and when to seek medical attention.
Patient Guidelines
- Take exactly as prescribed by your doctor; do not stop abruptly without medical advice.
- Take with food or milk to reduce stomach upset.
- Report any unusual side effects, especially severe mood changes, swelling, or signs of infection.
- Carry a steroid card if on long-term treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Sonipred 5 mg Oral Solution may cause dizziness or visual disturbances in some patients. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet, low in sodium and high in potassium, calcium, and vitamin D.
- Engage in regular weight-bearing exercise to support bone health.
- Avoid exposure to people with infections, especially chickenpox or measles.
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