Medicine Information

tdcef

Name: tdcef
Brand: tdcef

Suspension100 mg per 5 mlAntibiotic, Cephalosporin (Third Generation)ATC: J01DD08

Generic Name

Cefixime 100 mg Suspension

Manufacturer

Reputable Pharmaceutical Company

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
tdcef 100 mg suspension	৳ 210.00	N/A

Description

Overview of the medicine

Cefixime is a broad-spectrum antibiotic belonging to the third-generation cephalosporin class, used to treat a wide range of bacterial infections in children and adults.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pharyngitis, tonsillitis)

Urinary tract infections (e.g., cystitis, pyelonephritis)

Otitis media (middle ear infection)

Gonorrhea (uncomplicated cervical/urethral)

Dosage

Adults

The usual adult dose for cefixime is 400 mg once daily or 200 mg every 12 hours (usually administered as tablets or higher strength suspension if available). For suspension specifically, adult dosing is less common.

Elderly

Same as adults, but dose adjustment may be required in elderly patients with significant renal impairment.

Renal_impairment

Dosage adjustment is necessary for patients with creatinine clearance less than 60 ml/min. Consult physician for specific guidelines.

How to Take

Administer orally, with or without food. Shake the suspension bottle well before each use. Use the provided measuring device to ensure accurate dosing.

Mechanism of Action

Cefixime works by inhibiting bacterial cell wall synthesis, leading to bactericidal action against susceptible organisms.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved within 2-6 hours after administration.

Excretion

Primarily renal excretion (approximately 50% unchanged drug in urine) and biliary/fecal excretion.

Half life

Approximately 3-4 hours.

Absorption

Approximately 40-50% orally absorbed. Food may delay time to peak concentration but does not significantly alter the extent of absorption.

Metabolism

Not extensively metabolized in the liver; approximately 50% of the absorbed dose is excreted unchanged.

Side Effects

Contraindications

Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
History of severe hypersensitivity reactions to penicillin antibiotics.

Drug Interactions

Nifedipine

May increase cefixime Cmax and AUC, though clinical significance is usually minimal.

Carbamazepine

Elevated carbamazepine levels have been reported with concurrent use. Monitor carbamazepine levels.

Diuretics (e.g., Furosemide)

May increase risk of nephrotoxicity when co-administered with other nephrotoxic drugs.

Oral Anticoagulants (e.g., Warfarin)

Increased prothrombin time (PT) with or without bleeding. Close monitoring of coagulation parameters is recommended.

Storage

Store the dry powder below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children. Reconstituted suspension should be stored in the refrigerator.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive.

Pregnancy & Lactation

Pregnancy Category B. Cefixime should be used during pregnancy only if clearly needed. Use with caution during lactation as small amounts may pass into breast milk.

Side Effects

Contraindications

Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
History of severe hypersensitivity reactions to penicillin antibiotics.

Drug Interactions

Nifedipine

May increase cefixime Cmax and AUC, though clinical significance is usually minimal.

Carbamazepine

Elevated carbamazepine levels have been reported with concurrent use. Monitor carbamazepine levels.

Diuretics (e.g., Furosemide)

May increase risk of nephrotoxicity when co-administered with other nephrotoxic drugs.

Oral Anticoagulants (e.g., Warfarin)

Increased prothrombin time (PT) with or without bleeding. Close monitoring of coagulation parameters is recommended.

Storage

Store the dry powder below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children. Reconstituted suspension should be stored in the refrigerator.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive.

Pregnancy & Lactation

Pregnancy Category B. Cefixime should be used during pregnancy only if clearly needed. Use with caution during lactation as small amounts may pass into breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 ml suspension50 ml suspension75 ml suspension100 ml suspension

Shelf Life

Unreconstituted powder: 2-3 years. Reconstituted suspension: 7-14 days when stored in a refrigerator (2-8°C).

Availability

Available in pharmacies and hospitals

Approval Status

Approved by health authorities worldwide

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections, particularly in pediatric and adult populations for respiratory, urinary, and ear infections.

Lab Monitoring

Periodic monitoring of renal function is recommended during prolonged therapy, especially in patients with pre-existing renal impairment.
Complete blood count (CBC) may be monitored during extended treatment durations.

Doctor Notes

Consider local resistance patterns when prescribing.
Adjust dose in patients with renal impairment.
Counsel patients on the importance of completing the full course of therapy, even if symptoms improve.

Patient Guidelines

Complete the entire prescribed course of medication, even if symptoms improve, to prevent the development of antibiotic resistance.
Do not share this medication with others.
If you experience severe diarrhea, especially with blood or mucus, contact your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.