Tdcef
Generic Name
Cefixime 400 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
tdcef 400 mg tablet | ৳ 50.00 | ৳ 300.00 |
Description
Overview of the medicine
Tdcef 400 mg Tablet contains Cefixime, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, and gonorrhoea.
Uses & Indications
Dosage
Adults
The usual adult dose is 400 mg once daily or 200 mg every 12 hours for 7 to 14 days, depending on the infection.
Elderly
No dosage adjustment is generally required for elderly patients with normal renal function.
Renal_impairment
For patients with creatinine clearance <60 mL/min, dosage adjustment is necessary. For creatinine clearance <20 mL/min, 200 mg once daily is recommended.
How to Take
Tdcef 400 mg Tablet can be taken with or without food. It is important to complete the full course of treatment as prescribed by your doctor, even if you start feeling better.
Mechanism of Action
Cefixime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This leads to the disruption of bacterial cell wall formation and eventual cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-6 hours after oral administration.
Excretion
Approximately 50% of an absorbed dose is excreted unchanged in the urine over 24 hours. A small amount is excreted in bile.
Half life
Average plasma half-life is 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect overall absorption.
Metabolism
Cefixime is not extensively metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any penicillin (due to potential cross-reactivity).
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing the risk of bleeding.
Carbamazepine
Cefixime may increase carbamazepine levels.
Storage
Store in a cool, dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Caution should be exercised when administered to a nursing woman as small amounts may be excreted in breast milk.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any penicillin (due to potential cross-reactivity).
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing the risk of bleeding.
Carbamazepine
Cefixime may increase carbamazepine levels.
Storage
Store in a cool, dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Caution should be exercised when administered to a nursing woman as small amounts may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with pre-existing renal impairment.
- Complete blood count (CBC) if prolonged therapy is anticipated.
Doctor Notes
- Consider culture and susceptibility testing for appropriate therapy.
- Adjust dose in severe renal impairment.
- Educate patients on the importance of completing the full course.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Complete the entire course of treatment, even if symptoms improve.
- Do not share your medicine with others.
- Consult your doctor if side effects worsen or new symptoms appear.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tdcef 400 mg Tablet generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid these activities until you feel well.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Ensure adequate rest to support recovery.
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