Turbocef
Generic Name
Cefixime 125 mg/5 ml Suspension
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| turbocef 125 mg suspension | ৳ 240.00 | N/A |
Description
Overview of the medicine
Cefixime is an oral third-generation cephalosporin antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria. It is commonly used to treat various bacterial infections in children.
Uses & Indications
Dosage
Adults
Not typically recommended for adults in this strength/form. Adult dosages of Cefixime are usually 200-400 mg tablets, once or twice daily.
Elderly
Not applicable for this strength/form, as it is primarily for pediatric use. Dosage adjustment may be required for elderly patients with severe renal impairment.
Renal_impairment
For children with CrCl < 30 ml/min, dosage adjustment is required. The dose should be reduced by 50% or the dosing interval extended.
How to Take
Oral administration. Shake the bottle well before each use to ensure uniform suspension. Can be taken with or without food. Use the provided measuring device for accurate dosing.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the final transpeptidation step of peptidoglycan synthesis, leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Onset of action depends on the infection type and severity; generally, clinical improvement seen within 24-48 hours.
Excretion
Primarily excreted unchanged in urine via glomerular filtration and tubular secretion (about 50%), and some through biliary excretion.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly affect the extent.
Metabolism
Not extensively metabolized in the body. Primary metabolic pathway involves desacetylation.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Probenecid
May increase Cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Concomitant use may increase carbamazepine plasma concentrations.
Warfarin and other anticoagulants
May increase prothrombin time (PT) and International Normalized Ratio (INR), leading to an increased risk of bleeding. Close monitoring is recommended.
Storage
Store the dry powder below 30°C, away from moisture and direct sunlight. Keep the reconstituted suspension in a refrigerator (2-8°C) and protect from light.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive care and symptomatic treatment are recommended.
Pregnancy & Lactation
Pregnancy: Cefixime is classified as Pregnancy Category B. Studies in animals have not shown harm to the fetus. Use during pregnancy only if clearly needed. Lactation: Small amounts of Cefixime are excreted in breast milk. Caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Probenecid
May increase Cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Concomitant use may increase carbamazepine plasma concentrations.
Warfarin and other anticoagulants
May increase prothrombin time (PT) and International Normalized Ratio (INR), leading to an increased risk of bleeding. Close monitoring is recommended.
Storage
Store the dry powder below 30°C, away from moisture and direct sunlight. Keep the reconstituted suspension in a refrigerator (2-8°C) and protect from light.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive care and symptomatic treatment are recommended.
Pregnancy & Lactation
Pregnancy: Cefixime is classified as Pregnancy Category B. Studies in animals have not shown harm to the fetus. Use during pregnancy only if clearly needed. Lactation: Small amounts of Cefixime are excreted in breast milk. Caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: 2-3 years. Reconstituted suspension: 7-14 days when stored in a refrigerator (2-8°C), depending on manufacturer instructions.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved (DGDA, Bangladesh)
Patent Status
Patent expired for Cefixime
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections, particularly in pediatric populations. Ongoing research focuses on antibiotic resistance patterns and new formulations.
Lab Monitoring
- Complete Blood Count (CBC) with differential in prolonged therapy
- Renal function tests (BUN, creatinine) in patients with pre-existing renal impairment or during prolonged treatment
Doctor Notes
- Consider culture and susceptibility testing before initiating treatment, especially in recurrent or severe infections.
- Adjust dosage in pediatric patients with severe renal impairment.
- Counsel parents on the importance of completing the full course of therapy.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve, to prevent resistance and recurrence.
- Shake the suspension well before each use.
- Do not share your medication with others.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime generally does not impair ability to drive or operate machinery. However, rare instances of dizziness have been reported. Patients should be cautious until they know how they react to the medication.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid self-medication and always consult a doctor before starting any new medicine.
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