vita-d3
Generic Name
Cholecalciferol 2000 IU
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vita d3 2000 iu tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Vita-D3 2000 IU Tablet contains Cholecalciferol, which is essential for calcium and phosphate absorption, bone health, and immune system function. It is used to prevent and treat Vitamin D deficiency and associated conditions.
Uses & Indications
Dosage
Adults
For prevention of Vitamin D deficiency: 2000 IU (1 tablet) daily. For treatment of deficiency, higher doses may be prescribed by a physician based on serum 25(OH)D levels.
Elderly
Similar to adult dosage. Older adults may have reduced skin synthesis of Vitamin D and may require supplementation.
Renal_impairment
Use with caution. High doses may lead to hypercalcemia. Active forms of Vitamin D may be preferred in severe renal failure. Consult a physician.
How to Take
Take the tablet orally, preferably with the largest meal of the day to enhance absorption. Do not chew or crush the tablet, swallow it whole with water.
Mechanism of Action
Cholecalciferol (Vitamin D3) is biologically inactive but is converted in the liver to 25-hydroxycholecalciferol (calcidiol) and then in the kidneys to the active form, 1,25-dihydroxycholecalciferol (calcitriol). Calcitriol acts on specific vitamin D receptors to regulate calcium and phosphate homeostasis, promoting their absorption from the gut and reabsorption in the kidneys, and influencing bone mineralization.
Pharmacokinetics
Onset
Therapeutic effects on calcium and phosphate levels typically become noticeable after several days to weeks of regular dosing.
Excretion
Excreted primarily in the bile and feces. A small amount is excreted in the urine.
Half life
The elimination half-life of cholecalciferol is approximately 24 hours, but its hydroxylated metabolites have longer half-lives. Stored in fat tissue, the total body half-life can be several months.
Absorption
Cholecalciferol is well absorbed from the gastrointestinal tract, especially in the presence of bile salts and dietary fat. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Initially hydroxylated in the liver to 25-hydroxycholecalciferol (calcidiol), which is the major circulating form. Further hydroxylated in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the biologically active form.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any excipients
- Hypercalcemia (high calcium levels in blood)
- Hypervitaminosis D (excessive Vitamin D levels)
- Severe renal impairment with hyperphosphatemia
- Nephrolithiasis (kidney stones)
Drug Interactions
Corticosteroids
May reduce the effects of Vitamin D.
Thiazide Diuretics
May increase the risk of hypercalcemia.
Phenytoin/Barbiturates
May reduce the effect of Vitamin D by accelerating its metabolism.
Cholestyramine/Colestipol/Orlistat
May reduce the absorption of Vitamin D.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypervitaminosis D) include hypercalcemia with symptoms like nausea, vomiting, constipation, polyuria, polydipsia, weakness, headache, and in severe cases, kidney damage and cardiac arrhythmias. Management involves discontinuing the medicine, hydration, and medical supervision.
Pregnancy & Lactation
Cholecalciferol is generally considered safe during pregnancy and lactation at recommended doses. It is important for fetal bone development and infant health. However, high doses should be avoided. Consult your doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any excipients
- Hypercalcemia (high calcium levels in blood)
- Hypervitaminosis D (excessive Vitamin D levels)
- Severe renal impairment with hyperphosphatemia
- Nephrolithiasis (kidney stones)
Drug Interactions
Corticosteroids
May reduce the effects of Vitamin D.
Thiazide Diuretics
May increase the risk of hypercalcemia.
Phenytoin/Barbiturates
May reduce the effect of Vitamin D by accelerating its metabolism.
Cholestyramine/Colestipol/Orlistat
May reduce the absorption of Vitamin D.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypervitaminosis D) include hypercalcemia with symptoms like nausea, vomiting, constipation, polyuria, polydipsia, weakness, headache, and in severe cases, kidney damage and cardiac arrhythmias. Management involves discontinuing the medicine, hydration, and medical supervision.
Pregnancy & Lactation
Cholecalciferol is generally considered safe during pregnancy and lactation at recommended doses. It is important for fetal bone development and infant health. However, high doses should be avoided. Consult your doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, supermarkets, online stores
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ongoing clinical research investigates optimal dosing, its role in various chronic diseases (e.g., cardiovascular disease, diabetes, certain cancers), and immune modulation. Evidence supports its role in bone health.
Lab Monitoring
- Serum 25-hydroxyvitamin D levels (to assess Vitamin D status)
- Serum calcium levels
- Serum phosphate levels
- Renal function tests (e.g., creatinine, BUN) in patients with kidney impairment
Doctor Notes
- Assess serum 25(OH)D levels to determine baseline Vitamin D status and guide dosing.
- Monitor serum calcium and phosphate levels, especially in patients on high doses or with pre-existing conditions affecting calcium metabolism.
- Advise patients on dietary sources of Vitamin D and calcium, and the importance of moderate sun exposure.
Patient Guidelines
- Take the tablet as directed by your doctor or pharmacist.
- Preferably take with food to improve absorption.
- Do not exceed the recommended dose without consulting a healthcare professional.
- Inform your doctor about all other medications you are taking, including supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Vita-D3 2000 IU Tablet is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and Vitamin D.
- Engage in moderate sun exposure to naturally boost Vitamin D levels, but avoid excessive exposure without protection.
- Regular physical activity is beneficial for bone health.
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