Vita-D3
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
General Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vita d3 20000 iu capsule | ৳ 20.00 | ৳ 100.00 |
Description
Overview of the medicine
Vita-D3 20000 IU Capsule contains Cholecalciferol, which is Vitamin D3. It is used to treat and prevent vitamin D deficiency, a condition that can lead to bone problems like rickets in children and osteomalacia in adults. It plays a crucial role in maintaining calcium and phosphate levels in the body, which are essential for bone health.
Uses & Indications
Dosage
Adults
For severe Vitamin D deficiency, typically 20,000 IU once weekly for 7 weeks, followed by a maintenance dose as per doctor's advice. Dosing may vary based on serum 25(OH)D levels and clinical condition.
Elderly
Similar to adults, but monitoring for hypercalcemia may be more frequent, especially in those with reduced renal function.
Renal_impairment
Use with caution. Monitoring of calcium and phosphate levels is essential. Dose adjustment may be necessary. Not recommended for severe renal failure without specific guidance.
How to Take
Take the capsule orally, preferably with the largest meal of the day to enhance absorption. Do not chew or crush the capsule; swallow it whole with water.
Mechanism of Action
Cholecalciferol is a precursor to the active form of Vitamin D (calcitriol). It is hydroxylated in the liver to 25-hydroxyvitamin D (calcidiol) and then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol), the active hormone. Calcitriol acts to maintain normal blood levels of calcium and phosphorus by promoting their absorption from the intestine, increasing bone mineralization, and affecting bone remodeling.
Pharmacokinetics
Onset
Clinical effects on calcium and phosphate levels can be observed within days, but full repletion of Vitamin D stores takes weeks to months.
Excretion
Excreted primarily through bile into the feces. Small amounts are excreted renally.
Half life
The half-life of 25-hydroxyvitamin D (calcidiol), the main circulating form, is approximately 2-3 weeks.
Absorption
Cholecalciferol is readily absorbed from the small intestine, especially when taken with fatty meals. Absorption is dependent on the presence of bile salts.
Metabolism
Initially hydroxylated in the liver to 25-hydroxyvitamin D (calcidiol). Subsequently, in the kidneys, it is converted to the active form, 1,25-dihydroxyvitamin D (calcitriol).
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any component of the capsule.
- Hypercalcemia (high blood calcium levels).
- Hypervitaminosis D (excessive Vitamin D levels).
- Severe renal impairment (unless prescribed by a specialist with strict monitoring).
Drug Interactions
Corticosteroids
May reduce the effects of vitamin D.
Digitalis/Digoxin
Increased risk of cardiac arrhythmias due to hypercalcemia.
Thiazide diuretics
May increase the risk of hypercalcemia.
Anticonvulsants (e.g., phenytoin, barbiturates)
May accelerate vitamin D metabolism, reducing its effectiveness.
Cholestyramine, Colestipol, Orlistat, Mineral oil
May impair absorption of fat-soluble vitamin D.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia (nausea, vomiting, constipation, polyuria, polydipsia, muscle weakness, confusion). In severe cases, it can lead to kidney damage and cardiac arrhythmias. Management involves discontinuing vitamin D, hydration, and medical supervision to correct calcium levels.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. However, high doses (like 20,000 IU weekly) should only be used under strict medical supervision when the potential benefits outweigh the risks. Excessive vitamin D can be harmful to the fetus or infant. Monitoring of maternal and infant vitamin D and calcium levels is recommended.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any component of the capsule.
- Hypercalcemia (high blood calcium levels).
- Hypervitaminosis D (excessive Vitamin D levels).
- Severe renal impairment (unless prescribed by a specialist with strict monitoring).
Drug Interactions
Corticosteroids
May reduce the effects of vitamin D.
Digitalis/Digoxin
Increased risk of cardiac arrhythmias due to hypercalcemia.
Thiazide diuretics
May increase the risk of hypercalcemia.
Anticonvulsants (e.g., phenytoin, barbiturates)
May accelerate vitamin D metabolism, reducing its effectiveness.
Cholestyramine, Colestipol, Orlistat, Mineral oil
May impair absorption of fat-soluble vitamin D.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia (nausea, vomiting, constipation, polyuria, polydipsia, muscle weakness, confusion). In severe cases, it can lead to kidney damage and cardiac arrhythmias. Management involves discontinuing vitamin D, hydration, and medical supervision to correct calcium levels.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. However, high doses (like 20,000 IU weekly) should only be used under strict medical supervision when the potential benefits outweigh the risks. Excessive vitamin D can be harmful to the fetus or infant. Monitoring of maternal and infant vitamin D and calcium levels is recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on the specific product and storage conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have established the efficacy and safety of cholecalciferol in treating and preventing vitamin D deficiency. Ongoing research continues to explore optimal dosing strategies and its role in various health conditions beyond bone health.
Lab Monitoring
- Serum 25(OH)D levels (to assess vitamin D status)
- Serum calcium levels (to monitor for hypercalcemia)
- Serum phosphate levels
- Renal function tests (e.g., creatinine, eGFR) in patients with renal impairment or at risk.
Doctor Notes
- Emphasize the importance of patient education regarding the signs and symptoms of hypercalcemia.
- Ensure regular monitoring of serum 25(OH)D and calcium levels, especially during initial therapy and dose adjustments.
- Consider potential drug interactions, particularly with thiazide diuretics, digoxin, and anticonvulsants.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose without medical advice.
- Report any unusual symptoms or side effects to your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Vita-D3 is not expected to affect the ability to drive or operate machinery. However, if symptoms of hypercalcemia (e.g., fatigue, confusion) occur, caution should be exercised.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D sources.
- Moderate sun exposure (if appropriate) can help in natural vitamin D production.
- Engage in regular weight-bearing exercises to support bone health.
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