Vita-D3
Generic Name
Cholecalciferol 40000 IU Capsule
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vita d3 40000 iu capsule | ৳ 35.00 | ৳ 175.00 |
Description
Overview of the medicine
Vita-D3 40000 IU Capsule contains Cholecalciferol (Vitamin D3), a fat-soluble vitamin essential for calcium and phosphate absorption and utilization, critical for bone health, immune function, and overall well-being. This high-strength formulation is typically used for the treatment and prevention of severe vitamin D deficiency.
Uses & Indications
Dosage
Adults
For severe deficiency, 40000 IU orally once weekly for 7-10 weeks, followed by maintenance dose (e.g., 800-2000 IU daily).
Elderly
Same as adults, but monitor for hypercalcemia due to potential reduced renal function.
Renal_impairment
Use with caution. Dosage adjustment may be required; monitor calcium and phosphate levels. Not recommended in severe renal impairment without expert advice.
How to Take
Oral administration. Capsules should be swallowed whole with water, preferably with a meal to enhance absorption of this fat-soluble vitamin.
Mechanism of Action
Cholecalciferol is converted in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidneys to the active form, 1,25-dihydroxyvitamin D (calcitriol). Calcitriol promotes intestinal absorption of calcium and phosphate, enhances renal reabsorption of calcium, and regulates bone mineralization. It also plays a role in immune modulation and cell growth.
Pharmacokinetics
Onset
Effects on calcium levels typically seen within days to weeks.
Excretion
Excreted primarily in bile and feces; a small amount is excreted in urine.
Half life
Circulating half-life of 25-hydroxyvitamin D is approximately 15-30 days; active 1,25-dihydroxyvitamin D has a shorter half-life of 4-6 hours.
Absorption
Readily absorbed from the small intestine, primarily in the presence of bile salts.
Metabolism
Metabolized in the liver to 25-hydroxyvitamin D and then in the kidneys to 1,25-dihydroxyvitamin D (active form) and other inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any excipients
- Hypercalcemia (high calcium levels in blood)
- Hypervitaminosis D (vitamin D toxicity)
- Nephrolithiasis (kidney stones)
- Severe renal impairment (without close monitoring)
Drug Interactions
Corticosteroids
May reduce the effects of vitamin D.
Thiazide diuretics
May increase the risk of hypercalcemia.
Cardiac glycosides (e.g., Digoxin)
Hypercalcemia induced by vitamin D can increase the toxicity of cardiac glycosides.
Orlistat, Cholestyramine, mineral oil
May reduce absorption of vitamin D.
Anticonvulsants (e.g., Phenytoin, Barbiturates)
May accelerate vitamin D metabolism, reducing its effects.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia, hypercalciuria, nausea, vomiting, constipation, anorexia, polyuria, polydipsia, weakness, fatigue, headache, and in severe cases, renal impairment or cardiac arrhythmias. Treatment involves discontinuing vitamin D, reducing calcium intake, hydration, and in severe cases, corticosteroids or calcitonin.
Pregnancy & Lactation
Pregnancy: Adequate vitamin D intake is essential during pregnancy. High doses should only be used if clearly indicated and under medical supervision, as excessive amounts can be harmful. Lactation: Cholecalciferol passes into breast milk. Use with caution during breastfeeding and monitor infant for signs of hypercalcemia.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any excipients
- Hypercalcemia (high calcium levels in blood)
- Hypervitaminosis D (vitamin D toxicity)
- Nephrolithiasis (kidney stones)
- Severe renal impairment (without close monitoring)
Drug Interactions
Corticosteroids
May reduce the effects of vitamin D.
Thiazide diuretics
May increase the risk of hypercalcemia.
Cardiac glycosides (e.g., Digoxin)
Hypercalcemia induced by vitamin D can increase the toxicity of cardiac glycosides.
Orlistat, Cholestyramine, mineral oil
May reduce absorption of vitamin D.
Anticonvulsants (e.g., Phenytoin, Barbiturates)
May accelerate vitamin D metabolism, reducing its effects.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia, hypercalciuria, nausea, vomiting, constipation, anorexia, polyuria, polydipsia, weakness, fatigue, headache, and in severe cases, renal impairment or cardiac arrhythmias. Treatment involves discontinuing vitamin D, reducing calcium intake, hydration, and in severe cases, corticosteroids or calcitonin.
Pregnancy & Lactation
Pregnancy: Adequate vitamin D intake is essential during pregnancy. High doses should only be used if clearly indicated and under medical supervision, as excessive amounts can be harmful. Lactation: Cholecalciferol passes into breast milk. Use with caution during breastfeeding and monitor infant for signs of hypercalcemia.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials support the efficacy of cholecalciferol in treating and preventing vitamin D deficiency and its associated conditions. Ongoing research explores its role in immune health, cardiovascular disease, and certain cancers.
Lab Monitoring
- Serum calcium levels
- Serum phosphate levels
- 25-hydroxyvitamin D levels
- Renal function (creatinine, eGFR)
Doctor Notes
- Assess baseline vitamin D and calcium levels before initiating high-dose therapy.
- Monitor serum calcium, phosphate, and 25(OH)D levels regularly during treatment.
- Educate patients on symptoms of hypercalcemia.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any signs of vitamin D toxicity (e.g., nausea, vomiting, excessive thirst, weakness) immediately.
- Regular blood tests may be required to monitor calcium and vitamin D levels.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Vita-D3 is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium.
- Get adequate sun exposure (if medically appropriate) to support natural vitamin D production.
- Engage in regular weight-bearing exercise for bone health.
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