Vita-D3
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Reputable Pharmaceutical Co.
Country
Global
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vita d3 200000 iu injectable solution oral im | ৳ 120.00 | N/A |
Description
Overview of the medicine
A high-dose Vitamin D3 (Cholecalciferol) supplement used to treat and prevent Vitamin D deficiency, especially in severe cases or malabsorption. It can be administered orally or intramuscularly.
Uses & Indications
Dosage
Adults
Varies widely based on deficiency severity. For severe deficiency, 200,000 IU (oral/IM) once monthly or every 2-3 months until levels normalize, as directed by a physician.
Elderly
Similar to adults, but caution with renal impairment. Monitor calcium and phosphate levels.
Renal_impairment
Use with caution. Monitor calcium and phosphate levels. May require active Vitamin D forms (calcitriol) if renal conversion is impaired. Not recommended in severe impairment with hyperphosphatemia.
How to Take
Oral administration: The solution can be consumed directly or mixed with food/drink. Intramuscular administration: Administered by a healthcare professional deep into a muscle, typically the gluteal muscle.
Mechanism of Action
Cholecalciferol is converted in the body to calcitriol, the active form of Vitamin D, which regulates calcium and phosphate homeostasis, bone metabolism, and immune function.
Pharmacokinetics
Onset
Days to weeks for full effect, depending on baseline levels.
Excretion
Primarily excreted in bile/feces; small amounts in urine.
Half life
Variable. Calcifediol (25-OHD3) has a half-life of about 2-3 weeks, calcitriol (1,25-(OH)2D3) has a half-life of 4-6 hours. This high dose is stored in fat tissue and released slowly.
Absorption
Well absorbed from the gastrointestinal tract, especially with fatty meals. Intramuscular administration bypasses first-pass metabolism.
Metabolism
Metabolized in the liver to 25-hydroxycholecalciferol (calcifediol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form.
Side Effects
Contraindications
- Hypercalcemia (high calcium levels in blood)
- Hypervitaminosis D (Vitamin D toxicity)
- Hypersensitivity to cholecalciferol or any excipients
- Severe renal impairment with hyperphosphatemia
Drug Interactions
Digoxin
Hypercalcemia can increase digoxin toxicity.
Corticosteroids
May reduce Vitamin D effects and intestinal calcium absorption.
Thiazide diuretics
May increase the risk of hypercalcemia.
Orlistat, Cholestyramine, Mineral oil
May reduce absorption of fat-soluble vitamins, including Vitamin D.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase Vitamin D metabolism, reducing its effect.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, thirst, polyuria, constipation, muscle weakness, confusion, fatigue). Severe cases can lead to renal damage and cardiac arrhythmias. Treatment involves discontinuing Vitamin D, low calcium diet, hydration, and potentially corticosteroids or bisphosphonates under medical supervision.
Pregnancy & Lactation
Generally safe in pregnancy and lactation at recommended doses. High doses can be teratogenic and should be avoided. Consult a doctor before use.
Side Effects
Contraindications
- Hypercalcemia (high calcium levels in blood)
- Hypervitaminosis D (Vitamin D toxicity)
- Hypersensitivity to cholecalciferol or any excipients
- Severe renal impairment with hyperphosphatemia
Drug Interactions
Digoxin
Hypercalcemia can increase digoxin toxicity.
Corticosteroids
May reduce Vitamin D effects and intestinal calcium absorption.
Thiazide diuretics
May increase the risk of hypercalcemia.
Orlistat, Cholestyramine, Mineral oil
May reduce absorption of fat-soluble vitamins, including Vitamin D.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase Vitamin D metabolism, reducing its effect.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, thirst, polyuria, constipation, muscle weakness, confusion, fatigue). Severe cases can lead to renal damage and cardiac arrhythmias. Treatment involves discontinuing Vitamin D, low calcium diet, hydration, and potentially corticosteroids or bisphosphonates under medical supervision.
Pregnancy & Lactation
Generally safe in pregnancy and lactation at recommended doses. High doses can be teratogenic and should be avoided. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
Clinical Trials
Extensive clinical data and trials support the efficacy and safety of cholecalciferol in treating and preventing Vitamin D deficiency. Specific trials for this high-dose formulation focus on dosing regimens and long-term outcomes.
Lab Monitoring
- Serum 25-hydroxyvitamin D levels (to assess Vitamin D status)
- Serum calcium levels
- Serum phosphate levels
- Renal function tests (e.g., creatinine, eGFR)
Doctor Notes
- Emphasize careful monitoring of serum calcium and 25(OH)D levels, especially during initial therapy and dose adjustments.
- Educate patients thoroughly on the signs and symptoms of hypercalcemia and when to seek immediate medical attention.
- Consider the patient's overall calcium intake (dietary and supplemental) when prescribing high-dose Vitamin D.
Patient Guidelines
- Take or receive this medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose without consulting your doctor.
- Report any unusual or severe symptoms, especially signs of hypercalcemia (e.g., increased thirst, frequent urination, nausea, vomiting).
- Ensure adequate intake of dietary calcium through food or supplements as advised by your doctor.
- Inform your doctor about all other medications and supplements you are taking.
Missed Dose Advice
Since this is a high-dose, infrequent administration, a missed dose should be administered as soon as remembered, unless it's almost time for the next scheduled dose. Consult your doctor for specific advice.
Driving Precautions
Cholecalciferol is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and other essential nutrients.
- Engage in regular outdoor activities to allow for natural sunlight exposure, which aids in Vitamin D production.
- Avoid excessive sun exposure without protection.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Vita-D3 Brand
Other medicines available under the same brand name
