Medicine Information

3-bion

Name: 3-bion
Brand: 3-bion
Rating: 4.5 (117 reviews)

TabletThiamine HCl 100 mg, Pyridoxine HCl 200 mg, Cyanocobalamin 200 mcgB-complex vitamins, Neurotrophic vitaminsATC: A11DB

Generic Name

Thiamine HCl, Pyridoxine HCl, Cyanocobalamin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
3 bion 100 mg tablet	৳ 12.00	৳ 120.00

Description

Overview of the medicine

3-bion 100 mg Tablet is a combination of three essential B vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) crucial for nerve health, metabolism, and overall well-being. It is primarily used to treat and prevent vitamin B deficiencies and associated neurological conditions.

Uses & Indications

Treatment and prevention of Vitamin B1, B6, and B12 deficiencies.

Peripheral neuropathy (e.g., diabetic neuropathy, alcoholic neuropathy).

Neuralgia, neuritis, sciatica.

Supportive therapy in various neurological disorders.

General debility and convalescence.

Dosage

Adults

Usually 1-3 tablets daily, or as directed by the physician. The dosage may vary depending on the severity of the deficiency or condition.

Elderly

No specific dosage adjustment is typically required for elderly patients, same as adults, unless significant renal impairment is present.

Renal_impairment

Generally, no dosage adjustment is needed for mild to moderate renal impairment. For severe impairment or high doses, consult a physician due to potential accumulation of pyridoxine.

How to Take

3-bion 100 mg Tablet should be taken orally with water. It can be taken with or without food. Follow the physician's instructions regarding dose and duration.

Mechanism of Action

Thiamine (Vitamin B1) is essential for carbohydrate metabolism and nerve impulse transmission. Pyridoxine (Vitamin B6) is involved in amino acid metabolism and neurotransmitter synthesis. Cyanocobalamin (Vitamin B12) is crucial for DNA synthesis, red blood cell formation, and maintaining the myelin sheath around nerves.

Pharmacokinetics

Onset

Therapeutic effects, especially for neurological symptoms, may be gradual, appearing over days to weeks.

Excretion

Mainly renal (via urine).

Half life

Thiamine: approximately 18-36 hours; Pyridoxine: about 15-20 days (due to tissue storage); Cyanocobalamin: about 6 days, with long-term tissue storage.

Absorption

Well absorbed orally. Thiamine and Pyridoxine are absorbed primarily in the small intestine. Cyanocobalamin absorption requires intrinsic factor and occurs in the ileum.

Metabolism

Primarily hepatic (in the liver).

Side Effects

Contraindications

Hypersensitivity to Thiamine, Pyridoxine, Cyanocobalamin, or any other component of the tablet.

Drug Interactions

Levodopa

Pyridoxine may reduce the efficacy of levodopa (used without a decarboxylase inhibitor like carbidopa) by increasing its peripheral metabolism.

Metformin

Long-term use of metformin may reduce Vitamin B12 absorption.

Folic Acid

Large doses of folic acid can mask a Vitamin B12 deficiency.

Phenobarbital and Phenytoin

High doses of pyridoxine may decrease serum concentrations of phenobarbital and phenytoin.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Overdose is rare with water-soluble vitamins. Very high, prolonged doses of Pyridoxine (Vitamin B6) may lead to peripheral neuropathy. Management is symptomatic and supportive. Discontinue the drug and consult a doctor.

Pregnancy & Lactation

Generally considered safe during pregnancy and lactation at recommended dosages. However, high doses should be used only if clearly needed and under medical supervision. Consult a doctor before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

3 x 10 tablets (30 tablets in a box)

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Pharmacies, hospitals

Approval Status

Approved (DGDA, Bangladesh)

Patent Status

Off-patent

Clinical Trials

Individual components (Thiamine, Pyridoxine, Cyanocobalamin) have extensive clinical data. The combination is widely used based on the established efficacy of its components in addressing vitamin deficiencies and neurological support.

Lab Monitoring

Not routinely required for general use.
May be monitored for vitamin B levels in cases of severe deficiency or malabsorption syndromes.

Doctor Notes

Effective supportive therapy for various neuropathies.
Generally well-tolerated with a good safety profile.
Educate patients on the importance of adherence and potential for B6-induced neuropathy at excessive doses.

Patient Guidelines

Take the tablet exactly as prescribed by your doctor.
Do not exceed the recommended dose without medical advice.
Inform your doctor about all other medications you are taking.
Report any unusual side effects promptly.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

3-bion 100 mg Tablet is not known to impair the ability to drive or operate machinery.

Lifestyle Advice

Maintain a balanced diet rich in essential nutrients.
Regular exercise and a healthy lifestyle can enhance overall well-being.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Neuro-B (Beximco Pharmaceuticals Ltd.)B-Bion (Acme Laboratories Ltd.)Vitabion (ACI Limited)Esdron (Eskayef Pharmaceuticals Ltd.)

Global Brand Names

International brand names for this medicine