Medicine Information

Expreso Plus

Name: Expreso Plus
Brand: Expreso Plus
Rating: 4.5 (117 reviews)

Tablet10 mg, 20 mgCNS Stimulant / PsychostimulantATC: N06BA

Generic Name

Expreso

Manufacturer

Pharma Beximco

Country

Bangladesh

Loading images...

Description

Overview of the medicine

Expreso is a central nervous system (CNS) stimulant used to improve alertness and reduce fatigue in conditions like excessive daytime sleepiness and attention deficit disorder.

Uses & Indications

Excessive daytime sleepiness (e.g., Narcolepsy, OSA)

Attention Deficit Disorder (ADD/ADHD)

Chronic fatigue syndrome (off-label)

Dosage

Adults

Initial dose of 10 mg once daily in the morning. May be adjusted up to 20 mg once daily based on response and tolerability.

Elderly

Lower initial doses (e.g., 5 mg) may be considered, with careful titration due to potential increased sensitivity and comorbidities.

Renal_impairment

Dose adjustment may be necessary. Initiate with a lower dose and monitor for adverse effects.

How to Take

Expreso tablets can be taken with or without food. It is generally recommended to take the medicine in the morning to avoid insomnia.

Mechanism of Action

It works by selectively blocking adenosine receptors in the brain, which leads to increased neuronal activity and enhanced alertness without significant peripheral stimulation.

Pharmacokinetics

Onset

Effects typically begin within 30-60 minutes.

Excretion

Mainly excreted as metabolites in the urine.

Half life

Approximately 8-12 hours.

Absorption

Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours.

Metabolism

Primarily metabolized in the liver via CYP450 enzyme system, especially CYP1A2.

Side Effects

Contraindications

Hypersensitivity to Expreso or any component of the formulation
Uncontrolled hypertension
Severe cardiovascular disease (e.g., recent myocardial infarction, unstable angina)
Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy.

Drug Interactions

MAOIs

Concomitant use is contraindicated due to risk of hypertensive crisis.

Sympathomimetics

May enhance the effects of other sympathomimetic agents, increasing risk of cardiovascular adverse effects.

CYP1A2 Inhibitors/Inducers

Dose adjustment may be needed with drugs affecting CYP1A2 metabolism (e.g., cimetidine, fluvoxamine, rifampicin).

Storage

Store below 25°C, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include severe agitation, insomnia, tremor, tachycardia, hypertension, hallucinations, and seizures. Treatment is supportive, including gastric lavage, activated charcoal, and symptomatic management.

Pregnancy & Lactation

Expreso should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if Expreso is excreted in human milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

3 years from the date of manufacture.

Availability

Pharmacies and Hospitals

Approval Status

Approved

Patent Status

Patented

Clinical Trials

Clinical trials have demonstrated the efficacy of Expreso in improving wakefulness and reducing symptoms of attention deficit in adult patients.

Lab Monitoring

Regular monitoring of blood pressure and heart rate is recommended, especially at the initiation of therapy and after dose adjustments.
Liver function tests may be considered periodically.

Doctor Notes

Assess patient's cardiovascular history and psychiatric status before initiating Expreso.
Educate patients on potential for abuse and importance of adherence to prescribed dosage.
Monitor for signs of agitation, insomnia, and blood pressure changes.

Patient Guidelines

Do not stop taking Expreso abruptly without consulting your doctor, as withdrawal symptoms may occur.
Take the medication exactly as prescribed by your healthcare provider.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is close to the time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not double the dose.

Driving Precautions

Expreso may cause dizziness, restlessness, or impaired judgment in some individuals. Patients should assess their response to the drug before driving or operating heavy machinery.