Adults

Typically, 250 mg/62.5 mg tablet three times daily (every 8 hours) for 7-10 days, depending on the severity and type of infection. Higher doses may be used for severe infections.

Elderly

No dose adjustment is generally required unless there is severe renal impairment. Monitor renal function.

Renal_impairment

Dose adjustment is required for patients with creatinine clearance < 30 mL/min. For example, 250 mg/62.5 mg every 12-24 hours.

Onset

Typically within 1 hour.

Excretion

Primarily excreted unchanged by the kidneys, via glomerular filtration and tubular secretion. A small portion is excreted in feces.

Half life

Amoxicillin: 1-1.5 hours; Clavulanate: 1 hour.

Absorption

Rapidly and well absorbed after oral administration, bioavailability is approximately 70% for both components. Food can slightly delay absorption but does not significantly affect total absorption.

Metabolism

Both components are minimally metabolized; Amoxicillin undergoes partial metabolism to inactive metabolites. Clavulanate is more extensively metabolized.

Probenecid

Increases and prolongs plasma levels of amoxicillin (not clavulanate).

Methotrexate

May increase methotrexate toxicity; monitor levels.

Oral contraceptives

May reduce efficacy of oral contraceptives (use alternative contraception).

Anticoagulants (e.g., Warfarin)

May prolong prothrombin time; monitor INR.