Medicine Information

Avloclav

Name: Avloclav
Brand: Avloclav

TabletAmoxicillin 250 mg / Clavulanate Potassium 62.5 mgAntibiotics - PenicillinsATC: J01CR02

Generic Name

Amoxicillin and Clavulanate Potassium

Manufacturer

Popular Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
avloclav 250 mg tablet	৳ 27.00	৳ 162.00

Description

Overview of the medicine

Avloclav 250 mg tablet contains amoxicillin, a penicillin antibiotic, and clavulanate potassium, a beta-lactamase inhibitor. It is used to treat bacterial infections that are resistant to amoxicillin alone.

Uses & Indications

Upper and lower respiratory tract infections (e.g., sinusitis, otitis media, bronchitis, pneumonia)

Urinary tract infections (e.g., cystitis, pyelonephritis)

Skin and soft tissue infections (e.g., cellulitis, animal bites)

Odontogenic infections

Dosage

Adults

Typically, 250 mg/62.5 mg tablet three times daily (every 8 hours) for 7-10 days, depending on the severity and type of infection. Higher doses may be used for severe infections.

Elderly

No dose adjustment is generally required unless there is severe renal impairment. Monitor renal function.

Renal_impairment

Dose adjustment is required for patients with creatinine clearance < 30 mL/min. For example, 250 mg/62.5 mg every 12-24 hours.

How to Take

Administer orally at the start of a meal to minimize potential gastrointestinal intolerance and enhance absorption. Take with a full glass of water.

Mechanism of Action

Amoxicillin inhibits bacterial cell wall synthesis. Clavulanate potassium inactivates beta-lactamase enzymes produced by bacteria, thereby extending amoxicillin's spectrum of activity against beta-lactamase producing strains.

Pharmacokinetics

Onset

Typically within 1 hour.

Excretion

Primarily excreted unchanged by the kidneys, via glomerular filtration and tubular secretion. A small portion is excreted in feces.

Half life

Amoxicillin: 1-1.5 hours; Clavulanate: 1 hour.

Absorption

Rapidly and well absorbed after oral administration, bioavailability is approximately 70% for both components. Food can slightly delay absorption but does not significantly affect total absorption.

Metabolism

Both components are minimally metabolized; Amoxicillin undergoes partial metabolism to inactive metabolites. Clavulanate is more extensively metabolized.

Side Effects

Contraindications

History of severe hypersensitivity reactions (e.g., anaphylaxis) to beta-lactam antibiotics (e.g., penicillins, cephalosporins)
History of amoxicillin-clavulanate-associated jaundice or hepatic dysfunction

Drug Interactions

Probenecid

Increases and prolongs plasma levels of amoxicillin (not clavulanate).

Methotrexate

May increase methotrexate toxicity; monitor levels.

Oral contraceptives

May reduce efficacy of oral contraceptives (use alternative contraception).

Anticoagulants (e.g., Warfarin)

May prolong prothrombin time; monitor INR.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include gastrointestinal upset, rash, or convulsions (in patients with impaired renal function or high doses). Treatment is supportive; hemodialysis can remove amoxicillin and clavulanate.

Pregnancy & Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; use with caution during breastfeeding.

Side Effects

Contraindications

History of severe hypersensitivity reactions (e.g., anaphylaxis) to beta-lactam antibiotics (e.g., penicillins, cephalosporins)
History of amoxicillin-clavulanate-associated jaundice or hepatic dysfunction

Drug Interactions

Probenecid

Increases and prolongs plasma levels of amoxicillin (not clavulanate).

Methotrexate

May increase methotrexate toxicity; monitor levels.

Oral contraceptives

May reduce efficacy of oral contraceptives (use alternative contraception).

Anticoagulants (e.g., Warfarin)

May prolong prothrombin time; monitor INR.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; use with caution during breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip20 tablets per box

Shelf Life

Typically 24-36 months from manufacturing date

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory authorities

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied in clinical trials for its efficacy and safety in various bacterial infections.

Lab Monitoring

Liver function tests (especially with prolonged use or in patients with hepatic impairment)
Renal function tests (for patients with renal impairment or prolonged use)
Complete blood count (for prolonged therapy)

Doctor Notes

Counsel patients on the importance of completing the full course of therapy.
Be aware of potential hypersensitivity reactions, especially in patients with a history of penicillin allergy.
Monitor for signs of hepatotoxicity and pseudomembranous colitis.
Adjust dose in renal impairment.

Patient Guidelines

Complete the full course of antibiotics as prescribed, even if you feel better.
Do not share this medicine with others.
If you develop severe diarrhea, especially with blood or mucus, contact your doctor immediately.
Report any signs of allergic reactions (e.g., rash, difficulty breathing) to your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.