Avloclav
Generic Name
Amoxicillin + Clavulanic Acid 500 mg Tablet
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| avloclav 500 mg tablet | ৳ 35.00 | ৳ 210.00 |
Description
Overview of the medicine
Avloclav 500 mg tablet is a combination antibiotic containing amoxicillin and clavulanic acid. It is used to treat a wide range of bacterial infections that are resistant to amoxicillin alone due to beta-lactamase production.
Uses & Indications
Dosage
Adults
The usual adult dose is one Avloclav 500 mg/125 mg tablet taken three times daily (every 8 hours). Dosage should be adjusted based on the severity of infection and patient's renal function.
Elderly
No specific dose adjustment is generally required for elderly patients unless there is evidence of renal impairment.
Renal_impairment
Dose adjustment is necessary for patients with renal impairment. For CrCl 10-30 mL/min, 500 mg/125 mg every 12 hours. For CrCl <10 mL/min, 500 mg/125 mg every 24 hours. Hemodialysis patients should receive 500 mg/125 mg every 24 hours, with an additional dose given during and at the end of dialysis.
How to Take
Take the tablet whole with a glass of water. To minimize potential gastrointestinal intolerance, take at the start of a meal. Do not crush or chew.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Clavulanic acid is a beta-lactamase inhibitor that prevents the degradation of amoxicillin by bacterial beta-lactamase enzymes, thereby extending amoxicillin's antibacterial spectrum.
Pharmacokinetics
Onset
Onset of action typically within 1 hour.
Excretion
Both amoxicillin and clavulanic acid are primarily excreted unchanged in the urine, mainly by tubular secretion and glomerular filtration.
Half life
Amoxicillin: Approximately 1-1.5 hours; Clavulanic acid: Approximately 1 hour.
Absorption
Both amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within approximately 1-2 hours.
Metabolism
Amoxicillin undergoes minimal metabolism. Clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- Hypersensitivity to amoxicillin, clavulanic acid, any penicillin, or any component of the formulation.
- History of severe hypersensitivity reaction to any other beta-lactam antibiotic (e.g., cephalosporins, carbapenems, monobactams).
- History of jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid.
Drug Interactions
Probenecid
Decreases renal tubular secretion of amoxicillin, leading to increased and prolonged blood levels of amoxicillin. Concomitant use is not recommended.
Allopurinol
Increased incidence of skin rash when co-administered with amoxicillin.
Methotrexate
May increase methotrexate toxicity due to reduced renal tubular secretion of methotrexate.
Warfarin and other oral anticoagulants
May prolong prothrombin time (INR). Close monitoring of INR is recommended.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include gastrointestinal symptoms such as stomach pain, vomiting, and diarrhea, as well as electrolyte imbalance. Management is primarily symptomatic and supportive, with attention to fluid and electrolyte balance. Hemodialysis can be used to remove amoxicillin/clavulanate from circulation.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, use in pregnancy should be undertaken only if clearly needed. Amoxicillin and clavulanic acid are excreted into breast milk. Exercise caution when administering to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to amoxicillin, clavulanic acid, any penicillin, or any component of the formulation.
- History of severe hypersensitivity reaction to any other beta-lactam antibiotic (e.g., cephalosporins, carbapenems, monobactams).
- History of jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid.
Drug Interactions
Probenecid
Decreases renal tubular secretion of amoxicillin, leading to increased and prolonged blood levels of amoxicillin. Concomitant use is not recommended.
Allopurinol
Increased incidence of skin rash when co-administered with amoxicillin.
Methotrexate
May increase methotrexate toxicity due to reduced renal tubular secretion of methotrexate.
Warfarin and other oral anticoagulants
May prolong prothrombin time (INR). Close monitoring of INR is recommended.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include gastrointestinal symptoms such as stomach pain, vomiting, and diarrhea, as well as electrolyte imbalance. Management is primarily symptomatic and supportive, with attention to fluid and electrolyte balance. Hemodialysis can be used to remove amoxicillin/clavulanate from circulation.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, use in pregnancy should be undertaken only if clearly needed. Amoxicillin and clavulanic acid are excreted into breast milk. Exercise caution when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, consult packaging for exact date.
Availability
Pharmacies, Hospitals
Approval Status
Approved in many countries
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of amoxicillin/clavulanic acid for various bacterial infections. Ongoing research focuses on antibiotic resistance patterns and new formulations.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in patients with pre-existing hepatic impairment or during prolonged treatment.
- Renal function tests (creatinine, BUN) in patients with renal impairment or during prolonged treatment.
- Complete blood count (CBC) for prolonged therapy.
Doctor Notes
- Emphasize the importance of completing the full course to prevent resistance.
- Advise patients to report any signs of allergic reactions immediately.
- Be aware of potential drug interactions, especially with anticoagulants and methotrexate.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve.
- Take the medicine with food to reduce stomach upset.
- Report any severe or persistent side effects to your doctor.
- Do not share this medication with others.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medication may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol during treatment as it may exacerbate stomach upset.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Avloclav Brand
Other medicines available under the same brand name
Avloclav
Tablet
Avloclav
Powder for Injection
Avloclav
Oral Suspension
Avloclav
Powder for Injection
Avloclav
Tablet