Medicine Information

Cefracef

Name: Cefracef
Brand: Cefracef
Rating: 4.5 (117 reviews)

Capsule500 mgAntibiotics (First-Generation Cephalosporins)ATC: J01DC04

Generic Name

Cefaclor

Manufacturer

Healthcare Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cefracef 500 mg capsule	৳ 15.00	৳ 60.00

Description

Overview of the medicine

Cefaclor is a cephalosporin antibiotic used to treat various bacterial infections, including those of the respiratory tract, urinary tract, and skin.

Uses & Indications

Upper and lower respiratory tract infections (e.g., pharyngitis, pneumonia)

Urinary tract infections (e.g., cystitis)

Skin and soft tissue infections

Otitis media (middle ear infection)

Dosage

Adults

250-500 mg every 8 hours, depending on the severity and type of infection. Maximum 4 g/day.

Elderly

Similar to adult dosage, but renal function should be assessed and dosage adjusted if necessary.

Renal_impairment

Dosage adjustment required for severe impairment (e.g., CrCl < 10 mL/min). A loading dose may be given, followed by reduced maintenance doses.

How to Take

Take orally with or without food. Complete the full prescribed course.

Mechanism of Action

Cefaclor inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Onset of action varies by infection type, generally within hours of administration.

Excretion

Primarily excreted unchanged by the kidneys in urine via glomerular filtration and tubular secretion.

Half life

Approximately 0.6-1 hour.

Absorption

Rapidly and well absorbed from the GI tract. Food may delay absorption but does not significantly alter the total amount absorbed.

Metabolism

Not significantly metabolized in the body.

Side Effects

Contraindications

Known hypersensitivity to cefaclor or any other cephalosporin antibiotics.
History of severe hypersensitivity reaction to penicillin.

Drug Interactions

Metformin

Cefaclor may increase plasma levels of metformin.

Probenecid

Increases cefaclor plasma concentrations and prolongs its half-life by inhibiting renal excretion.

Aminoglycosides

Although rare, concurrent use with some cephalosporins may increase the risk of nephrotoxicity.

Warfarin and oral anticoagulants

May enhance the anticoagulant effect, requiring monitoring of INR.

Storage

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management includes gastric lavage, activated charcoal, and supportive care. Hemodialysis may be useful in severe cases.

Pregnancy & Lactation

Pregnancy Category B. Cefaclor crosses the placenta but is not associated with adverse fetal outcomes. Use with caution during lactation; small amounts are excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules (1x10's)30 capsules (3x10's)

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Expired

Clinical Trials

Cefaclor has undergone extensive clinical trials to establish its efficacy and safety in various bacterial infections before its approval and subsequent marketing.

Lab Monitoring

Renal function tests (for prolonged therapy or in patients with pre-existing renal impairment)
Liver function tests (rarely indicated, but consider in patients with hepatic dysfunction)

Doctor Notes

Confirm bacterial etiology before prescribing.
Inquire about penicillin allergy history due to potential cross-reactivity.
Advise patients to complete the entire course to minimize resistance development.
Monitor for signs of pseudomembranous colitis if severe diarrhea occurs.

Patient Guidelines

Complete the full course of antibiotics as prescribed by your doctor, even if symptoms improve.
Do not skip doses or share this medicine with others.
Inform your doctor about any history of allergies, especially to penicillin or other antibiotics.
Report any severe or persistent diarrhea to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.

Driving Precautions

This medicine may cause dizziness in some individuals. Exercise caution when driving or operating machinery until you know how it affects you.

Lifestyle Advice

Maintain good hygiene to prevent reinfection.
Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
Avoid alcohol during the course of treatment as it may exacerbate side effects like nausea.