Medicine Information

Ciprocin

Name: Ciprocin
Brand: Ciprocin

Eye Drop0.3% w/vOphthalmic Anti-infectives, FluoroquinolonesATC: S01AE07

Generic Name

Ciprofloxacin 0.3% Eye Drop

Manufacturer

Example Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ciprocin 03 eye drop	৳ 50.00	N/A

Description

Overview of the medicine

Ciprofloxacin 0.3% Eye Drop is an antibiotic medication used to treat bacterial infections of the eye, such as conjunctivitis, keratitis, and corneal ulcers. It belongs to the fluoroquinolone class of antibiotics.

Uses & Indications

Bacterial conjunctivitis

Bacterial keratitis

Corneal ulcers caused by susceptible bacteria

Dosage

Adults

For bacterial conjunctivitis: 1-2 drops into the affected eye(s) every 4 hours for 5-7 days. For severe infections/corneal ulcers: 2 drops every 15 minutes for 6 hours, then 2 drops every 30 minutes for 18 hours, then 2 drops every hour for 6 hours, then 2 drops every 4 hours for remaining treatment duration.

Elderly

No specific dosage adjustment is necessary for elderly patients.

Renal_impairment

No dosage adjustment is required for ophthalmic use.

How to Take

For ophthalmic use only. Tilt your head back, pull down your lower eyelid to create a pouch, and instill the prescribed number of drops into the conjunctival sac. Close your eye gently for 1-2 minutes. Do not touch the dropper tip to any surface.

Mechanism of Action

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination. This leads to the disruption of bacterial DNA and cell death.

Pharmacokinetics

Onset

Rapid onset of action locally, with bacterial eradication beginning within hours.

Excretion

Primarily local action; any minimally absorbed drug is renally excreted.

Half life

Systemic half-life is not clinically significant for ophthalmic use due to minimal absorption; local duration of action is related to dosing frequency.

Absorption

Minimal systemic absorption occurs following ophthalmic administration, leading to high local concentrations in ocular tissues.

Metabolism

Minimal systemic metabolism due to negligible absorption.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or any other quinolone antibiotics
Hypersensitivity to any excipients in the formulation

Drug Interactions

Systemic interactions

Systemic drug interactions are unlikely due to minimal systemic absorption from ophthalmic administration. However, if multiple eye drops are used, administer them at least 5 minutes apart.

Storage

Store below 25°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Ophthalmic overdose is unlikely to cause systemic toxicity. In case of accidental ingestion or excessive topical application, flush eyes with lukewarm water.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted in human milk after oral administration; however, systemic exposure from ophthalmic drops is minimal, and risk to a breastfed infant is considered low. Consult a doctor.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or any other quinolone antibiotics
Hypersensitivity to any excipients in the formulation

Drug Interactions

Systemic interactions

Systemic drug interactions are unlikely due to minimal systemic absorption from ophthalmic administration. However, if multiple eye drops are used, administer them at least 5 minutes apart.

Storage

Store below 25°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Ophthalmic overdose is unlikely to cause systemic toxicity. In case of accidental ingestion or excessive topical application, flush eyes with lukewarm water.

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 ml bottle10 ml bottle

Shelf Life

30 months (unopened). Discard 28 days after opening.

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory bodies

Patent Status

Off-patent (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of ciprofloxacin ophthalmic solution for treating various bacterial eye infections, demonstrating its broad-spectrum antibacterial activity.

Lab Monitoring

No specific laboratory monitoring is typically required for ophthalmic ciprofloxacin use.

Doctor Notes

Emphasize patient compliance with the full course of treatment to prevent recurrence and resistance.
Advise patients on proper instillation technique to maximize efficacy and minimize contamination.
Instruct patients to seek immediate medical attention if signs of severe allergic reaction or worsening infection occur.

Patient Guidelines

Remove contact lenses before applying the eye drops and wait at least 15 minutes before reinserting them.
Avoid touching the dropper tip to your eye or any other surface to prevent contamination.
Do not share your eye drops with others.
Complete the full course of treatment as prescribed, even if symptoms improve.

Missed Dose Advice

If you miss a dose, use it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.