Medicine Information

Ciprocin

Name: Ciprocin
Brand: Ciprocin

Injection (Intravenous Infusion)200 mg/100 mLQuinolone AntibioticsATC: J01MA02

Generic Name

Ciprofloxacin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ciprocin 200 mg injection	৳ 146.00	N/A

Description

Overview of the medicine

Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections, administered intravenously for systemic effect.

Uses & Indications

Complicated and uncomplicated urinary tract infections

Lower respiratory tract infections (e.g., exacerbation of chronic bronchitis, pneumonia)

Skin and soft tissue infections

Bone and joint infections

Intra-abdominal infections

Infectious diarrhea

Typhoid fever

Gonorrhea (when susceptible)

Anthrax (post-exposure)

Dosage

Adults

200-400 mg every 8-12 hours by slow intravenous infusion over 30-60 minutes, depending on the type and severity of infection. Doses may be increased in severe cases.

Elderly

Dosage adjustment may be needed based on renal function.

Renal_impairment

Dose reduction is required based on creatinine clearance (e.g., CrCl 30-60 mL/min: max 400 mg every 12 hours; CrCl <30 mL/min: max 400 mg every 18-24 hours).

How to Take

Administer by slow intravenous infusion over 30-60 minutes into a large vein. Do not administer intramuscularly or subcutaneously. Ensure adequate hydration.

Mechanism of Action

Inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.

Pharmacokinetics

Onset

Rapid (within minutes after IV administration).

Excretion

Primarily via renal excretion (both glomerular filtration and tubular secretion), with some non-renal clearance.

Half life

3 to 5 hours (can be prolonged in renal impairment).

Absorption

Rapid and complete systemic absorption (100% bioavailability) after intravenous administration. Peak plasma concentrations are achieved at the end of infusion.

Metabolism

Partially metabolized in the liver to less active metabolites.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other quinolones.
Concomitant administration with tizanidine.
Children and adolescents (except for specific severe infections where benefits outweigh risks).

Drug Interactions

Warfarin

Enhanced anticoagulant effects (monitor INR/PT).

Tizanidine

Increased tizanidine plasma concentrations, leading to hypotension and somnolence (contraindicated).

Cyclosporine

Increased serum creatinine and potential nephrotoxicity.

Methotrexate

Increased methotrexate plasma levels and potential toxicity.

Theophylline

Increased theophylline levels and toxicity (monitor levels).

Storage

Store below 30°C. Protect from light. Do not freeze.

Overdose

Symptoms may include renal toxicity, reversible renal impairment, and central nervous system effects (e.g., convulsions, tremors, confusion). Management is supportive and symptomatic; maintain hydration. Hemodialysis removes only small amounts of ciprofloxacin.

Pregnancy & Lactation

Pregnancy: Category C. Use only if potential benefit justifies the potential risk to the fetus. Lactation: Excreted into breast milk. Discontinue nursing or the drug.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other quinolones.
Concomitant administration with tizanidine.
Children and adolescents (except for specific severe infections where benefits outweigh risks).

Drug Interactions

Warfarin

Enhanced anticoagulant effects (monitor INR/PT).

Tizanidine

Increased tizanidine plasma concentrations, leading to hypotension and somnolence (contraindicated).

Cyclosporine

Increased serum creatinine and potential nephrotoxicity.

Methotrexate

Increased methotrexate plasma levels and potential toxicity.

Theophylline

Increased theophylline levels and toxicity (monitor levels).

Storage

Store below 30°C. Protect from light. Do not freeze.

Overdose

Pregnancy & Lactation

Pregnancy: Category C. Use only if potential benefit justifies the potential risk to the fetus. Lactation: Excreted into breast milk. Discontinue nursing or the drug.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 100 mL IV infusion bottle

Shelf Life

24 months from manufacturing date (typical for IV solutions)

Availability

Hospitals, Clinics, Pharmacies

Approval Status

Approved by regulatory authorities (e.g., DGDA, FDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Initial clinical trials established efficacy against various bacterial infections. Ongoing post-marketing surveillance continues to monitor for safety and rare adverse events.

Lab Monitoring

Renal function tests (creatinine, BUN)
Liver function tests (ALT, AST)
Complete blood count (CBC)
Electrolytes (especially potassium in patients with risk factors for QT prolongation)

Doctor Notes

Counsel patients on the black box warnings, particularly the risk of tendinopathy and neuropathy, and to seek immediate medical attention if symptoms occur.
Monitor renal function in elderly and renally impaired patients and adjust dosage accordingly.
Ensure adequate hydration to minimize the risk of crystalluria.

Patient Guidelines

Complete the full course of treatment as prescribed, even if symptoms improve, to prevent relapse and antibiotic resistance.
Report any tendon pain, numbness, tingling, or unusual muscle weakness immediately to your doctor.
Avoid excessive sun exposure due to the risk of photosensitivity.
Stay well-hydrated to help prevent crystalluria.

Missed Dose Advice

If a dose is missed, administer it as soon as remembered, unless it is almost time for the next dose. Do not double the dose.

Driving Precautions

May cause dizziness or lightheadedness, impairing ability to drive or operate machinery. Patients should be cautious until they know how the drug affects them.

Lifestyle Advice

Maintain good hygiene to prevent recurrence of infections.
Follow a balanced diet and engage in regular, moderate exercise (if appropriate for the condition).