Ciprocin
Generic Name
Ciprofloxacin 250 mg Suspension
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ciprocin 250 mg suspension | ৳ 100.30 | N/A |
Description
Overview of the medicine
Ciprofloxacin is a fluoroquinolone antibiotic used to treat a variety of bacterial infections. This suspension form is particularly suitable for children and adults who have difficulty swallowing tablets.
Uses & Indications
Dosage
Adults
Typically 250-750 mg twice daily, depending on the infection. Consult a physician for exact dosage.
Elderly
Dosage adjustment may be necessary in elderly patients with impaired renal function. Consult a physician.
Renal_impairment
Reduced dosage is required based on creatinine clearance. Consult a physician for specific guidelines.
How to Take
Administer orally, usually twice daily. Shake well before use. Can be taken with or without food, but avoid dairy products or calcium-fortified juices within 2 hours of administration.
Mechanism of Action
Inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Primarily excreted renally (approximately 50-70% as unchanged drug and active metabolites), with some non-renal excretion.
Half life
Approximately 3-5 hours in adults.
Absorption
Rapidly and well absorbed from the gastrointestinal tract; bioavailability is approximately 70-80%.
Metabolism
Partially metabolized in the liver to four active metabolites; however, the parent drug accounts for the majority of the systemic exposure.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other quinolones.
- Concomitant administration with tizanidine.
- History of tendinitis or tendon rupture associated with quinolone use.
Drug Interactions
Warfarin
Potentiation of anticoagulant effect, increased bleeding risk. Monitor INR closely.
Tizanidine
Contraindicated due to significant increase in tizanidine levels, leading to hypotension and sedation.
Theophylline
Increased serum concentrations of theophylline, leading to toxicity.
Corticosteroids
Increased risk of tendinitis/tendon rupture.
Antacids containing aluminum or magnesium
Reduced absorption of ciprofloxacin. Separate administration by at least 2 hours.
Storage
Store below 30°C, away from direct light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be performed. Provide symptomatic and supportive treatment. Maintain adequate hydration.
Pregnancy & Lactation
Use only if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor before use if pregnant or breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other quinolones.
- Concomitant administration with tizanidine.
- History of tendinitis or tendon rupture associated with quinolone use.
Drug Interactions
Warfarin
Potentiation of anticoagulant effect, increased bleeding risk. Monitor INR closely.
Tizanidine
Contraindicated due to significant increase in tizanidine levels, leading to hypotension and sedation.
Theophylline
Increased serum concentrations of theophylline, leading to toxicity.
Corticosteroids
Increased risk of tendinitis/tendon rupture.
Antacids containing aluminum or magnesium
Reduced absorption of ciprofloxacin. Separate administration by at least 2 hours.
Storage
Store below 30°C, away from direct light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be performed. Provide symptomatic and supportive treatment. Maintain adequate hydration.
Pregnancy & Lactation
Use only if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor before use if pregnant or breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for unopened product. Reconstituted suspension has a shorter shelf life, usually 14 days when stored properly.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Ciprofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety in treating a wide range of bacterial infections across various patient populations.
Lab Monitoring
- Renal function tests (creatinine, BUN) if impaired or for long-term treatment.
- Liver function tests (ALT, AST) if prolonged treatment or pre-existing liver disease.
- INR monitoring for patients on warfarin.
Doctor Notes
- Caution in patients with epilepsy or other CNS disorders due to increased risk of convulsions.
- Advise patients on potential photosensitivity reactions and the importance of adequate hydration to prevent crystalluria.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve, to prevent resistance.
- Drink plenty of fluids to prevent crystalluria and maintain kidney health.
- Avoid excessive sun exposure and use sunscreen due to photosensitivity.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double dose to make up for a missed one.
Driving Precautions
May cause dizziness, lightheadedness, or visual disturbances; caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent recurrence of infections.
- Avoid strenuous exercise if experiencing muscle or joint pain, especially in tendons.
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