Medicine Information

Ciprocin

Name: Ciprocin
Brand: Ciprocin

Tablet750 mgQuinolone antibioticsATC: J01MA02

Generic Name

Ciprofloxacin 750 mg Tablet

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ciprocin 750 mg tablet	৳ 18.12	৳ 181.20

Description

Overview of the medicine

Ciprocin 750 mg Tablet contains Ciprofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections.

Uses & Indications

Complicated and uncomplicated urinary tract infections (UTIs)

Respiratory tract infections (e.g., acute exacerbations of chronic bronchitis, pneumonia)

Skin and soft tissue infections

Bone and joint infections

Gastrointestinal infections (e.g., infectious diarrhea, typhoid fever)

Sexually transmitted diseases (gonorrhea)

Anthrax (post-exposure prophylaxis and treatment)

Dosage

Adults

Typical oral dosage ranges from 250 mg to 750 mg twice daily, depending on the type and severity of infection. For most severe infections or difficult-to-treat pathogens, 750 mg twice daily may be used. Duration varies from 5 to 14 days, or longer for bone/joint infections.

Elderly

No specific dosage adjustment is required based on age alone, but renal function should be assessed.

Renal_impairment

Dosage reduction is necessary in patients with creatinine clearance less than 50 mL/min. For CrCl 30-60 mL/min, maximum dose 500 mg twice daily. For CrCl <30 mL/min, maximum dose 500 mg once daily or 250 mg twice daily.

How to Take

Take the tablet orally with a glass of water, usually twice a day. It can be taken with or without food. However, avoid taking it with dairy products or calcium-fortified juices alone, as these can reduce absorption. Take antacids or supplements containing iron, zinc, or magnesium at least 2 hours before or 6 hours after Ciprocin.

Mechanism of Action

Ciprofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.

Pharmacokinetics

Onset

Within 1-2 hours for therapeutic effect.

Excretion

Primarily excreted renally by glomerular filtration and tubular secretion (50-70% as unchanged drug). Also excreted via feces (15-30%).

Half life

Approximately 3-5 hours.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, with bioavailability of about 70-80%. Peak plasma concentrations are achieved 1-2 hours after oral administration.

Metabolism

Undergoes limited hepatic metabolism (10-20%) to four active metabolites (desethyleneciprofloxacin, sulfociprofloxacin, oxociprofloxacin, and N-formylciprofloxacin), which have less antimicrobial activity than the parent drug.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other quinolones.
Co-administration with tizanidine due to increased risk of hypotension and sedation.
History of quinolone-associated tendinitis/tendon rupture.

Drug Interactions

Warfarin

May enhance the anticoagulant effect of warfarin, requiring INR monitoring.

Tizanidine

Concurrent use is contraindicated due to increased tizanidine plasma concentrations, leading to hypotension and sedation.

Theophylline

May increase plasma concentrations of theophylline, leading to toxicity. Monitor theophylline levels.

Corticosteroids

Increased risk of tendinitis and tendon rupture.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

Concurrent use may increase the risk of CNS stimulation and convulsive seizures.

Antacids/Mineral supplements (containing aluminum, magnesium, calcium, iron, zinc)

Reduce ciprofloxacin absorption. Administer Ciprocin at least 2 hours before or 6 hours after these products.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of acute overdose, reversible renal toxicity has been reported. Gastric lavage and supportive treatment are recommended. Maintain adequate hydration. Hemodialysis or peritoneal dialysis remove only a small amount of Ciprofloxacin.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk and may cause adverse effects in a nursing infant. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other quinolones.
Co-administration with tizanidine due to increased risk of hypotension and sedation.
History of quinolone-associated tendinitis/tendon rupture.

Drug Interactions

Warfarin

May enhance the anticoagulant effect of warfarin, requiring INR monitoring.

Tizanidine

Concurrent use is contraindicated due to increased tizanidine plasma concentrations, leading to hypotension and sedation.

Theophylline

May increase plasma concentrations of theophylline, leading to toxicity. Monitor theophylline levels.

Corticosteroids

Increased risk of tendinitis and tendon rupture.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

Concurrent use may increase the risk of CNS stimulation and convulsive seizures.

Antacids/Mineral supplements (containing aluminum, magnesium, calcium, iron, zinc)

Reduce ciprofloxacin absorption. Administer Ciprocin at least 2 hours before or 6 hours after these products.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister strip30 tablets per box

Shelf Life

36 months from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Ciprofloxacin has undergone extensive clinical trials supporting its efficacy and safety across various bacterial infections.

Lab Monitoring

Renal function tests (creatinine clearance, serum creatinine) in patients with renal impairment.
Liver function tests (ALT, AST) if liver dysfunction is suspected.
INR in patients concurrently on warfarin.
Blood glucose in diabetic patients.

Doctor Notes

Assess renal function before initiating and during therapy, especially in elderly patients or those with pre-existing renal impairment.
Counsel patients on the importance of hydration and to report any adverse events, particularly musculoskeletal or neurological symptoms, promptly.
Be aware of significant drug interactions, especially with tizanidine, warfarin, and theophylline.

Patient Guidelines

Complete the full course of treatment as prescribed, even if symptoms improve.
Stay well-hydrated while taking this medicine.
Avoid excessive sun exposure and use sunscreen, as Ciprocin can increase photosensitivity.
Report any tendon pain, swelling, or numbness/tingling immediately to your doctor.
Do not take Ciprocin with dairy products or calcium-fortified juices alone; separate by at least 2 hours.
Avoid driving or operating machinery until you know how Ciprocin affects you, as it may cause dizziness.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Ciprocin may cause dizziness or lightheadedness, which can impair your ability to drive or operate machinery. Exercise caution and avoid such activities if you experience these side effects.