Cortan
Generic Name
Hydrocortisone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cortan 1 suspension | ৳ 100.00 | N/A |
Description
Overview of the medicine
Cortan-1-suspension contains Hydrocortisone, a corticosteroid hormone used to treat a wide range of inflammatory and autoimmune conditions, as well as adrenal insufficiency. It acts as an anti-inflammatory and immunosuppressant agent.
Uses & Indications
Dosage
Adults
Dosage varies widely based on condition. For adrenocortical insufficiency, typically 20-30 mg daily in divided doses. For other conditions, doses range from 20-240 mg daily, tailored to individual response.
Elderly
Similar to adult dosage, but use with caution due to increased risk of side effects (e.g., osteoporosis, diabetes) and monitor for comorbidities.
Renal_impairment
No specific dosage adjustment is usually required in renal impairment; however, monitor for fluid retention and electrolyte disturbances.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal irritation. For chronic use, take in divided doses, mimicking the natural diurnal rhythm (e.g., two-thirds in the morning and one-third in the late afternoon).
Mechanism of Action
Hydrocortisone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene expression. This leads to the synthesis of anti-inflammatory proteins and inhibition of pro-inflammatory mediators, thereby reducing inflammation and suppressing immune responses.
Pharmacokinetics
Onset
The anti-inflammatory effects usually begin within a few hours of administration.
Excretion
Excreted mainly in the urine as inactive metabolites and, to a lesser extent, as unmetabolized drug.
Half life
Plasma half-life is approximately 80-118 minutes, but its biological half-life is 8-12 hours due to tissue binding.
Absorption
Hydrocortisone is well absorbed orally, with peak plasma concentrations occurring within 1-2 hours after administration.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system, and also in the kidney.
Side Effects
Contraindications
- •Systemic fungal infections
- •Known hypersensitivity to hydrocortisone or any component of the suspension
- •Live or live attenuated vaccines in patients receiving immunosuppressive doses
Drug Interactions
Warfarin
Increased or decreased anticoagulant effect; monitor INR.
NSAIDs (e.g., Ibuprofen)
Increased risk of gastrointestinal ulcers and bleeding.
Insulin/Oral hypoglycemics
Corticosteroids can increase blood glucose, requiring dose adjustments of antidiabetic medications.
Diuretics (e.g., Furosemide)
Increased potassium loss and risk of hypokalemia.
Oral contraceptives/Estrogens
May increase corticosteroid levels and effects.
Phenobarbital, Rifampin, Phenytoin
May reduce corticosteroid effects by increasing metabolism.
Storage
Store at controlled room temperature (20°C to 25°C), away from direct light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is rare and generally does not lead to life-threatening situations. Chronic overdose can lead to severe adverse effects of Cushing's syndrome, including fluid retention, hypertension, hyperglycemia, and adrenal suppression. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Hydrocortisone is excreted in breast milk; caution should be exercised when administered to a nursing mother. Monitor infants for signs of adrenal suppression.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when unopened. Refer to the manufacturer's label for specific expiry date. Once opened, use within a specified period (e.g., 28 days) as per manufacturer's guidelines.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available (Off-patent)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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