Cortan
Generic Name
Prednisolone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cortan 2 mg tablet | ৳ 0.80 | ৳ 8.00 |
Description
Overview of the medicine
Cortan 2 mg tablet contains Prednisolone, a synthetic corticosteroid. It is primarily used for its potent anti-inflammatory and immunosuppressive properties to treat a wide range of conditions including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Dosage varies widely based on condition and severity. Typical initial dose ranges from 5 mg to 60 mg daily, often tapered down. For Cortan 2mg, it might be used as part of a tapering regimen or for less severe conditions.
Elderly
Use with caution due to increased risk of side effects like osteoporosis and fluid retention. Lower initial doses may be appropriate.
Renal_impairment
No specific dose adjustment is usually required for renal impairment, but caution is advised in severe cases.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset. Do not crush or chew the tablet. Follow your doctor's instructions regarding dose and duration.
Mechanism of Action
Prednisolone acts by binding to glucocorticoid receptors in the cytoplasm, forming a complex that translocates into the nucleus. This complex then modulates gene expression, leading to the synthesis of anti-inflammatory proteins and the inhibition of pro-inflammatory mediators (e.g., prostaglandins, leukotrienes, cytokines). It also suppresses the immune response by inhibiting the function of lymphocytes and macrophages.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within a few hours.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Biological half-life is 18-36 hours; plasma half-life is 2-4 hours.
Absorption
Readily absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 1-2 hours after oral administration.
Metabolism
Primarily metabolized in the liver to inactive metabolites; converted to its active form, prednisolone, from prednisone.
Side Effects
Contraindications
- •Systemic fungal infections
- •Hypersensitivity to prednisolone or any component of the formulation
- •Live or live-attenuated vaccines during immunosuppressive doses of corticosteroids
Drug Interactions
Warfarin
Potentiates or inhibits the anticoagulant effect; monitor INR.
Antidiabetic agents
May increase blood glucose levels, requiring dose adjustment of antidiabetic drugs.
Oral contraceptives
May increase prednisolone effects.
Phenytoin, Phenobarbital, Rifampicin
May decrease prednisolone levels by increasing its metabolism.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased potassium loss.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration and bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include fluid retention, hypertension, and hyperglycemia. Management is primarily supportive and symptomatic. Gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution is advised during breastfeeding. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities in most countries (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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