Cortan
Generic Name
Prednisolone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cortan 20 mg tablet | ৳ 6.27 | ৳ 62.70 |
Description
Overview of the medicine
Cortan 20 mg Tablet contains Prednisolone, a corticosteroid used to treat a wide range of inflammatory and autoimmune conditions, as well as certain cancers. It works by reducing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Initial dosage varies from 5 mg to 60 mg daily, depending on the condition being treated. Tapering dose often required.
Elderly
Lower initial doses may be considered, and careful monitoring for side effects is important.
Renal_impairment
No specific dosage adjustment is usually required, but caution is advised in severe cases.
How to Take
Take orally, usually with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush, chew, or break.
Mechanism of Action
Prednisolone works by binding to glucocorticoid receptors in the cytoplasm, leading to a cascade of effects including altered gene expression. This results in anti-inflammatory and immunosuppressive actions by inhibiting the release of inflammatory mediators and suppressing immune cell function.
Pharmacokinetics
Onset
Varies depending on condition, but anti-inflammatory effects generally seen within hours.
Excretion
Excreted mainly in the urine as metabolites, with a small amount of unchanged drug.
Half life
Biological half-life is 18-36 hours, plasma half-life is 2-4 hours.
Absorption
Readily absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 1-2 hours after oral administration.
Metabolism
Primarily metabolized in the liver to inactive metabolites, including prednisolone succinate and prednisolone phosphate.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines during immunosuppressive doses of corticosteroids
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding.
Warfarin
Effects can be variable; monitor INR closely.
Oral Contraceptives
May increase prednisolone effects.
Diuretics (thiazide and loop)
Increased risk of hypokalemia.
Phenytoin, Rifampicin, Barbiturates
May reduce prednisolone effectiveness.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include mood swings, insomnia, fluid retention, and indigestion. Treatment is supportive; gradual withdrawal if chronic overdose is suspected.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Small amounts are excreted in breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines during immunosuppressive doses of corticosteroids
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding.
Warfarin
Effects can be variable; monitor INR closely.
Oral Contraceptives
May increase prednisolone effects.
Diuretics (thiazide and loop)
Increased risk of hypokalemia.
Phenytoin, Rifampicin, Barbiturates
May reduce prednisolone effectiveness.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include mood swings, insomnia, fluid retention, and indigestion. Treatment is supportive; gradual withdrawal if chronic overdose is suspected.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Small amounts are excreted in breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Prednisolone has been extensively studied in numerous clinical trials for its efficacy in various inflammatory and autoimmune conditions over many decades. Ongoing research explores new indications and optimized dosing regimens.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels (especially potassium)
- Blood pressure
- Bone mineral density (long-term use)
- Ophthalmological exams (long-term use)
Doctor Notes
- Educate patients on the importance of not stopping abruptly.
- Monitor for signs of infection, hyperglycemia, and osteoporosis.
- Consider calcium and vitamin D supplementation for long-term use.
- Advise patients about potential mood changes and insomnia.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor.
- Follow your doctor's dosage instructions carefully.
- Report any unusual side effects to your doctor immediately.
- Avoid contact with people who have infections like chickenpox or measles.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Prednisolone may cause dizziness or blurred vision in some individuals. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D.
- Engage in regular, moderate exercise.
- Limit alcohol intake.
- Avoid smoking.
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