Cortan
Generic Name
Prednisolone
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cortan 10 mg tablet | ৳ 3.23 | ৳ 32.30 |
Description
Overview of the medicine
Cortan 10 mg Tablet contains Prednisolone, a synthetic corticosteroid used for its potent anti-inflammatory and immunosuppressive properties. It is used to treat a wide range of conditions including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the condition being treated and patient response. Typically ranges from 5 mg to 60 mg daily, given as a single dose or divided doses. It should be tapered gradually to discontinue.
Elderly
Elderly patients may require lower doses and careful monitoring due to increased susceptibility to side effects and potential comorbidities.
Renal_impairment
No specific dose adjustment is typically required for renal impairment, but caution is advised in severe cases.
How to Take
Take Cortan 10 mg Tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet unless specifically advised by a doctor.
Mechanism of Action
Prednisolone works by binding to specific glucocorticoid receptors in the cytoplasm, forming a complex that translocates to the nucleus. This complex modulates gene expression, leading to the synthesis of anti-inflammatory proteins and the inhibition of pro-inflammatory mediators (e.g., prostaglandins, leukotrienes, cytokines). It also suppresses immune responses by reducing the activity of lymphocytes and other immune cells.
Pharmacokinetics
Onset
Anti-inflammatory effects can begin within 1-2 hours, but full therapeutic effect may take longer.
Excretion
Excreted mainly in the urine as inactive metabolites and, to a lesser extent, as unchanged drug. A small amount is excreted in the feces.
Half life
Plasma half-life is approximately 2-3 hours; however, the biological half-life is 18-36 hours due to prolonged tissue binding.
Absorption
Well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are typically reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites, including prednisolone 20-beta-dihydro.
Side Effects
Contraindications
- •Systemic fungal infections
- •Known hypersensitivity to prednisolone or any components of the formulation
- •Live vaccines administration in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
Antidiabetic agents
Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication.
Diuretics (Thiazide or Loop)
Increased risk of hypokalemia.
Anticoagulants (e.g., Warfarin)
Effects may be altered; close monitoring of INR/PT is required.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal bleeding and ulceration.
CYP3A4 Inducers (e.g., Phenobarbital, Rifampin)
May decrease prednisolone plasma concentrations, reducing its effectiveness.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase prednisolone plasma concentrations, increasing risk of side effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with prednisolone is rare and usually does not lead to life-threatening situations. Symptoms may include mood changes, insomnia, and gastrointestinal upset. Management is primarily supportive; no specific antidote exists. Long-term overdose can lead to severe adverse effects like Cushingoid features, adrenal suppression, and hypertension.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk and may cause adverse effects in nursing infants; a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, depending on the manufacturer.
Availability
Available in pharmacies worldwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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