Adults

Dosage varies widely based on condition. Typically 5-60 mg orally per day, in single or divided doses. For acute conditions, higher initial doses may be used, then tapered. Follow physician's instructions strictly.

Elderly

No specific dose adjustments are usually required, but caution is advised due to increased susceptibility to side effects. Lower starting doses may be considered.

Renal_impairment

No dosage adjustment is generally required for renal impairment, as prednisolone is primarily metabolized in the liver.

Onset

Anti-inflammatory effects typically begin within 1-2 hours; maximal suppression of inflammation may take several days.

Excretion

Excreted mainly in the urine, with a small amount excreted in the bile.

Half life

Plasma half-life: 2-4 hours; Biological half-life: 18-36 hours.

Absorption

Well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 1-2 hours after oral administration.

Metabolism

Primarily metabolized in the liver to inactive metabolites, including conjugation with glucuronic acid.

NSAIDs

Increased risk of gastrointestinal bleeding and ulceration.

Warfarin

May alter anticoagulant effects; monitor INR.

Cyclosporine

May increase plasma concentrations of both drugs.

Antidiabetic agents

May increase blood glucose levels, requiring adjustment of antidiabetic medication.

Diuretics (thiazide and loop)

May enhance potassium depletion.

Phenobarbital, Rifampin, Phenytoin

May reduce corticosteroid efficacy by increasing its metabolism.