Adults

Dosage varies widely based on condition and severity, typically 5-60 mg daily, taken as a single dose or in divided doses. Acute conditions may require higher initial doses followed by tapering. Oral solution can be dosed more precisely for lower doses.

Elderly

Use with caution; lower initial doses may be required due to increased susceptibility to side effects and potential comorbidities. Monitor for fluid retention and electrolyte imbalances.

Renal_impairment

No specific dose adjustment for renal impairment, but caution is advised in patients with severe renal disease due to potential fluid retention.

Onset

Onset of action varies depending on the condition being treated, generally within hours.

Excretion

Excreted mainly in the urine as inactive metabolites.

Half life

Plasma half-life is 2-4 hours; biological half-life is 18-36 hours.

Absorption

Readily absorbed from the gastrointestinal tract, achieving peak plasma concentrations within 1-2 hours.

Metabolism

Primarily metabolized in the liver to inactive metabolites, including prednisolone 20-beta-hydroxysulphate.

NSAIDS (e.g., Ibuprofen)

Increased risk of gastrointestinal bleeding and ulceration.

Diuretics (e.g., Furosemide)

Increased risk of hypokalemia.

Anticoagulants (e.g., Warfarin)

Effects may be altered; monitor INR closely.

Antidiabetic drugs (e.g., Insulin)

Prednisolone can increase blood glucose levels, requiring dose adjustments of antidiabetic drugs.

Immunosuppressants (e.g., Cyclosporine)

Increased immunosuppression and potential for higher blood levels of cyclosporine.