d-balance
Generic Name
Cholecalciferol (Vitamin D3) 2000 IU Oral Solution
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| d balance 2000 iu oral solution | ৳ 150.00 | N/A |
Description
Overview of the medicine
d-balance 2000 IU Oral Solution is a vitamin D3 (cholecalciferol) supplement used to prevent and treat vitamin D deficiency. It helps the body absorb calcium and phosphate, crucial for maintaining strong bones and teeth.
Uses & Indications
Dosage
Adults
For deficiency, 2000 IU daily or as directed by physician. For maintenance, 600-800 IU daily.
Elderly
Similar to adult dosage, but individual needs may vary; consult physician.
Renal_impairment
Use with caution; monitor calcium and phosphate levels.
How to Take
The oral solution can be taken directly or mixed with a small amount of food or drink. It is best taken with the largest meal of the day to enhance absorption.
Mechanism of Action
Cholecalciferol (Vitamin D3) is synthesized in the skin upon exposure to ultraviolet B (UVB) radiation and converted in the liver to 25-hydroxycholecalciferol (calcidiol). This is then converted in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form of vitamin D. Calcitriol acts by binding to vitamin D receptors, promoting calcium absorption from the gut, maintaining serum calcium and phosphate concentrations, and regulating bone mineralization.
Pharmacokinetics
Onset
Therapeutic effects typically evident within days to weeks.
Excretion
Excreted primarily in bile and feces, with a small amount excreted in urine.
Half life
The half-life of 25-hydroxyvitamin D3 is about 15-30 days; the active form 1,25-dihydroxyvitamin D3 has a half-life of 4-6 hours.
Absorption
Readily absorbed from the small intestine, especially with fatty meals.
Metabolism
Primarily hydroxylated in the liver to 25-hydroxycholecalciferol (calcidiol), then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol).
Side Effects
Contraindications
- •Hypercalcaemia (high calcium levels)
- •Hypervitaminosis D (vitamin D toxicity)
- •Nephrolithiasis (kidney stones)
- •Severe renal impairment without monitoring
Drug Interactions
Corticosteroids
May reduce vitamin D effects.
Cardiac glycosides
Increased risk of toxicity with hypercalcaemia.
Thiazide diuretics
May increase risk of hypercalcaemia.
Phenytoin/Barbiturates
May increase vitamin D metabolism.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
Symptoms include hypercalcaemia (nausea, vomiting, weakness, polyuria, polydipsia), hypercalciuria, and soft tissue calcification. Treatment involves stopping vitamin D, hydration, and medical management of hypercalcaemia.
Pregnancy & Lactation
Considered safe for use in pregnancy and lactation at recommended doses for treating or preventing deficiency. High doses should be avoided. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, drug stores, supermarkets
Approval Status
Approved by regulatory bodies (e.g., DGDA, FDA)
Patent Status
Off-patent
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Global Brand Names
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