Delight
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
PharmaCo Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| delight 200000 iu injectable solution oral im | ৳ 120.37 | N/A |
Description
Overview of the medicine
Delight 200,000 IU is a high-dose Cholecalciferol (Vitamin D3) preparation used for the treatment and prevention of Vitamin D deficiency, rickets, and osteomalacia. It can be administered orally or intramuscularly.
Uses & Indications
Dosage
Adults
For severe Vitamin D deficiency: 200,000 IU as a single dose, repeated after 3-6 months as advised by a physician. For maintenance: follow physician's guidance.
Elderly
Similar to adults, but careful monitoring of calcium levels is recommended due to potential age-related renal impairment.
Renal_impairment
Use with caution. Dosage adjustments may be necessary based on serum calcium and phosphate levels. Active Vitamin D metabolites may be preferred in severe renal failure.
How to Take
The solution can be taken orally, either directly or mixed with food/drink, or administered as an intramuscular injection by a healthcare professional. Follow specific instructions provided by the physician or pharmacist.
Mechanism of Action
Cholecalciferol (Vitamin D3) is biologically inert and is converted in the liver to 25-hydroxycholecalciferol (calcidiol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form of Vitamin D. Calcitriol is essential for maintaining calcium and phosphate homeostasis, promoting their absorption from the gut and regulating bone mineralization.
Pharmacokinetics
Onset
The full therapeutic effect may take days to weeks to manifest as cholecalciferol needs to be metabolized to its active form.
Excretion
Excreted primarily in the bile and feces, with a small amount excreted via the kidneys.
Half life
The elimination half-life of cholecalciferol is approximately 15-20 days, while the active metabolite calcitriol has a half-life of 3-6 hours.
Absorption
Well absorbed from the gastrointestinal tract when administered orally, especially in the presence of dietary fat. Rapidly absorbed from the intramuscular injection site.
Metabolism
Initially hydroxylated in the liver to 25-hydroxycholecalciferol (calcidiol), then further hydroxylated in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol).
Side Effects
Contraindications
- •Hypercalcemia (high calcium levels in the blood).
- •Hypersensitivity to Cholecalciferol or any component of the formulation.
- •Vitamin D toxicity.
- •Severe renal impairment (unless specifically managed by a specialist).
Drug Interactions
Corticosteroids
May counteract the effects of Vitamin D.
Cardiac glycosides
Increased risk of arrhythmias if hypercalcemia develops.
Thiazide diuretics
May increase the risk of hypercalcemia.
Phenytoin and Barbiturates
May accelerate the metabolism of Vitamin D, reducing its effectiveness.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose (hypervitaminosis D) include hypercalcemia, which can manifest as nausea, vomiting, constipation, polyuria, polydipsia, weakness, headache, and in severe cases, renal impairment and cardiac arrhythmias. Treatment involves discontinuing Vitamin D, hydrating the patient, and managing hypercalcemia with corticosteroids if necessary.
Pregnancy & Lactation
Adequate Vitamin D is important during pregnancy and lactation. However, high doses should be used with caution and only under strict medical supervision to avoid potential hypercalcemia in the mother or fetus. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic
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