Delight
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Reputable Pharmaceutical Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| delight 1000 iu tablet | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Delight 1000 IU Tablet contains Cholecalciferol, which is Vitamin D3. It is essential for calcium and phosphate absorption, playing a crucial role in maintaining strong bones and teeth. It also supports immune function and overall health.
Uses & Indications
Dosage
Adults
For prevention of Vitamin D deficiency, typically 1000-2000 IU daily. For treatment of mild deficiency, higher doses may be prescribed by a physician.
Elderly
Similar to adult dosage; however, some elderly individuals may require slightly higher doses due to reduced skin synthesis and absorption. Consult a doctor.
Renal_impairment
Use with caution. In severe renal impairment, direct supplementation with calcitriol (active Vitamin D) may be preferred. Consult a physician.
How to Take
Take the tablet orally with water. It can be taken with or without food, but absorption may be enhanced when taken with a meal containing some fat.
Mechanism of Action
Cholecalciferol (Vitamin D3) is biologically inactive and is converted in the liver to 25-hydroxycholecalciferol (calcifediol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form. Calcitriol promotes calcium absorption from the gastrointestinal tract, reabsorption of calcium in the renal tubules, and mobilization of calcium from bone. It also affects phosphate metabolism and has immunomodulatory properties.
Pharmacokinetics
Onset
The full therapeutic effect of Vitamin D supplementation may take several weeks to manifest as blood levels slowly increase and stabilize.
Excretion
Mainly excreted in the bile and feces, with only a small amount excreted in urine.
Half life
The elimination half-life of 25-hydroxyvitamin D (calcifediol), the major circulating form, is approximately 2-3 weeks. The active form, 1,25-dihydroxyvitamin D (calcitriol), has a half-life of about 15 hours.
Absorption
Cholecalciferol is readily absorbed from the small intestine, especially in the presence of bile salts and dietary fats.
Metabolism
Initially hydroxylated in the liver by 25-hydroxylase to 25-hydroxycholecalciferol, which is then further hydroxylated in the kidneys by 1-alpha-hydroxylase to the active form, 1,25-dihydroxycholecalciferol.
Side Effects
Contraindications
- •Hypersensitivity to Cholecalciferol or any component of the tablet.
- •Hypercalcemia (high levels of calcium in the blood).
- •Hypervitaminosis D (excessive levels of Vitamin D).
- •Severe renal impairment (unless under strict medical supervision and appropriate active Vitamin D forms are used).
Drug Interactions
Mineral oil
May interfere with absorption of fat-soluble vitamins including Vitamin D.
Corticosteroids
May reduce the effects of Vitamin D.
Thiazide diuretics
May increase the risk of hypercalcemia.
Digitalis glycosides
Hypercalcemia from Vitamin D can potentiate the effects of digitalis, leading to cardiac arrhythmias.
Cholestyramine, Colestipol
May impair absorption of Vitamin D.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase Vitamin D metabolism and reduce its effectiveness.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia, which can lead to nausea, vomiting, loss of appetite, constipation, excessive thirst, increased urination, muscle weakness, and fatigue. Severe cases can cause kidney damage and cardiac arrhythmias. Management involves discontinuing Vitamin D, reducing calcium intake, and maintaining hydration. Medical attention is required for severe overdose.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. Recommended daily allowances should be adhered to. Consult a doctor for appropriate dosage. Excessive doses should be avoided.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24 to 36 months from the date of manufacture, depending on the manufacturer.
Availability
Pharmacies, supermarkets, online stores
Approval Status
Approved by regulatory bodies
Patent Status
Generic
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