Medicine Information

Delight

Name: Delight
Brand: Delight
Rating: 4.5 (117 reviews)

Tablet1000 IUVitamin D preparationsATC: A11CC05

Generic Name

Cholecalciferol (Vitamin D3)

Manufacturer

Reputable Pharmaceutical Co.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
delight 1000 iu tablet	৳ 2.00	৳ 20.00

Description

Overview of the medicine

Delight 1000 IU Tablet contains Cholecalciferol, which is Vitamin D3. It is essential for calcium and phosphate absorption, playing a crucial role in maintaining strong bones and teeth. It also supports immune function and overall health.

Uses & Indications

Prevention and treatment of Vitamin D deficiency.

Support in osteoporosis management, often in conjunction with calcium.

Adjunct therapy for rickets and osteomalacia.

Maintenance of overall bone health.

Dosage

Adults

For prevention of Vitamin D deficiency, typically 1000-2000 IU daily. For treatment of mild deficiency, higher doses may be prescribed by a physician.

Elderly

Similar to adult dosage; however, some elderly individuals may require slightly higher doses due to reduced skin synthesis and absorption. Consult a doctor.

Renal_impairment

Use with caution. In severe renal impairment, direct supplementation with calcitriol (active Vitamin D) may be preferred. Consult a physician.

How to Take

Take the tablet orally with water. It can be taken with or without food, but absorption may be enhanced when taken with a meal containing some fat.

Mechanism of Action

Cholecalciferol (Vitamin D3) is biologically inactive and is converted in the liver to 25-hydroxycholecalciferol (calcifediol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form. Calcitriol promotes calcium absorption from the gastrointestinal tract, reabsorption of calcium in the renal tubules, and mobilization of calcium from bone. It also affects phosphate metabolism and has immunomodulatory properties.

Pharmacokinetics

Onset

The full therapeutic effect of Vitamin D supplementation may take several weeks to manifest as blood levels slowly increase and stabilize.

Excretion

Mainly excreted in the bile and feces, with only a small amount excreted in urine.

Half life

The elimination half-life of 25-hydroxyvitamin D (calcifediol), the major circulating form, is approximately 2-3 weeks. The active form, 1,25-dihydroxyvitamin D (calcitriol), has a half-life of about 15 hours.

Absorption

Cholecalciferol is readily absorbed from the small intestine, especially in the presence of bile salts and dietary fats.

Metabolism

Initially hydroxylated in the liver by 25-hydroxylase to 25-hydroxycholecalciferol, which is then further hydroxylated in the kidneys by 1-alpha-hydroxylase to the active form, 1,25-dihydroxycholecalciferol.

Side Effects

Contraindications

Hypersensitivity to Cholecalciferol or any component of the tablet.
Hypercalcemia (high levels of calcium in the blood).
Hypervitaminosis D (excessive levels of Vitamin D).
Severe renal impairment (unless under strict medical supervision and appropriate active Vitamin D forms are used).

Drug Interactions

Mineral oil

May interfere with absorption of fat-soluble vitamins including Vitamin D.

Corticosteroids

May reduce the effects of Vitamin D.

Thiazide diuretics

May increase the risk of hypercalcemia.

Digitalis glycosides

Hypercalcemia from Vitamin D can potentiate the effects of digitalis, leading to cardiac arrhythmias.

Cholestyramine, Colestipol

May impair absorption of Vitamin D.

Anticonvulsants (e.g., phenytoin, barbiturates)

May increase Vitamin D metabolism and reduce its effectiveness.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include hypercalcemia, which can lead to nausea, vomiting, loss of appetite, constipation, excessive thirst, increased urination, muscle weakness, and fatigue. Severe cases can cause kidney damage and cardiac arrhythmias. Management involves discontinuing Vitamin D, reducing calcium intake, and maintaining hydration. Medical attention is required for severe overdose.

Pregnancy & Lactation

Vitamin D is essential during pregnancy and lactation. Recommended daily allowances should be adhered to. Consult a doctor for appropriate dosage. Excessive doses should be avoided.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Blister pack of 30 tabletsBlister pack of 60 tablets

Shelf Life

Usually 24 to 36 months from the date of manufacture, depending on the manufacturer.

Availability

Pharmacies, supermarkets, online stores

Approval Status

Approved by regulatory bodies

Patent Status

Generic

Clinical Trials

Numerous clinical trials have investigated the role of Vitamin D in various health outcomes, including bone health, immune function, and chronic disease prevention. Ongoing research continues to explore its broader therapeutic potential.

Lab Monitoring

Serum 25(OH)D levels (to assess Vitamin D status).
Serum calcium levels (especially during high-dose therapy or in susceptible individuals).
Serum phosphate levels (occasionally).

Doctor Notes

Assess baseline Vitamin D levels (25(OH)D) before initiating high-dose therapy.
Monitor serum calcium and phosphate levels periodically, especially in patients with pre-existing conditions or on concomitant medications.
Counsel patients on dietary sources of Vitamin D and calcium, as well as safe sun exposure.

Patient Guidelines

Take the tablet as directed by your doctor or pharmacist.
Do not exceed the recommended dose without medical advice.
Inform your doctor about all other medications and supplements you are taking.
Maintain a balanced diet rich in calcium and get adequate sunlight exposure.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Delight 1000 IU Tablet is not known to affect the ability to drive or operate machinery.

Lifestyle Advice

Ensure adequate exposure to sunlight (about 10-15 minutes, 2-3 times a week, depending on skin type and time of day) for natural Vitamin D synthesis.
Incorporate calcium-rich foods like dairy products, leafy greens, and fortified foods into your diet.
Regular physical activity, especially weight-bearing exercises, helps maintain bone density.