Delight
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| delight 50000 iu capsule | ৳ 40.00 | ৳ 240.00 |
Description
Overview of the medicine
Delight 50000 IU Capsule contains Cholecalciferol, also known as Vitamin D3, which is essential for calcium and phosphate absorption and metabolism. It helps maintain healthy bones, teeth, and muscles.
Uses & Indications
Dosage
Adults
For severe deficiency: 50,000 IU once weekly for 6-8 weeks, followed by maintenance. For moderate deficiency: 50,000 IU once every 2-4 weeks. Maintenance: 800-2000 IU daily. (Specific dosage varies by condition and doctor's advice)
Elderly
Similar to adult dosage, but often requires careful monitoring due to potential for renal impairment.
Renal_impairment
Use with caution; may require lower doses or alternative forms of Vitamin D. Close monitoring of calcium and phosphate levels is necessary.
How to Take
Take orally with water, preferably with a meal containing fat to enhance absorption. Do not chew or crush the capsule.
Mechanism of Action
Cholecalciferol is converted in the liver to calcifediol and then in the kidneys to calcitriol (1,25-dihydroxyvitamin D), the active form. Calcitriol enhances calcium absorption from the intestine, promotes calcium reabsorption in the kidneys, and regulates bone mineralization and parathyroid hormone levels.
Pharmacokinetics
Onset
Gradual, effects usually seen after several weeks of therapy.
Excretion
Primarily via bile into the feces; small amounts excreted in urine.
Half life
Variable, ranging from several days to weeks depending on storage in adipose tissue. Active metabolite (calcitriol) has a half-life of 3-6 hours.
Absorption
Well absorbed from the gastrointestinal tract in the presence of bile salts.
Metabolism
Primarily in the liver to calcifediol (25-hydroxyvitamin D3), then in the kidneys to calcitriol (1,25-dihydroxyvitamin D3).
Side Effects
Contraindications
- •Hypercalcemia (high calcium levels in blood)
- •Hypervitaminosis D (excessive Vitamin D levels)
- •Malabsorption syndrome (unless treated)
- •Known hypersensitivity to Vitamin D or its components
- •Severe renal impairment with hyperphosphatemia
Drug Interactions
Corticosteroids
May reduce Vitamin D effects.
Thiazide Diuretics
May increase risk of hypercalcemia.
Phenytoin and Barbiturates
May accelerate Vitamin D metabolism, reducing its effects.
Cardiac Glycosides (e.g., Digoxin)
Hypercalcemia induced by Vitamin D may increase risk of digitalis toxicity.
Bile Acid Sequestrants (e.g., Cholestyramine, Colestipol) and Mineral Oil
May impair absorption of Vitamin D.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, constipation, anorexia, headache, weakness, and hypercalcemia. Severe overdose can lead to kidney damage. Treatment involves immediate discontinuation of the medicine, hydration, and management of hypercalcemia under medical supervision.
Pregnancy & Lactation
Adequate Vitamin D intake is important during pregnancy and lactation. However, high doses should be avoided. Consult your doctor before taking this medicine if you are pregnant or breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, drugstores.
Approval Status
Approved by regulatory authorities (e.g., DGDA) as a nutritional supplement.
Patent Status
Generic product, patents expired.
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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