Medicine Information

Dydron

Name: Dydron
Brand: Dydron
Rating: 4.5 (117 reviews)

Tablet10 mgProgestogensATC: G03DB01

Generic Name

Dydrogesterone

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dydron 10 mg tablet	৳ 40.00	৳ 400.00

Description

Overview of the medicine

Dydrogesterone is a synthetic progestogen used to treat a variety of gynaecological conditions caused by a lack of natural progesterone. These include threatened and habitual miscarriage, endometriosis, dysfunctional uterine bleeding, and as part of hormone replacement therapy.

Uses & Indications

Threatened and habitual miscarriage

Endometriosis

Dysfunctional uterine bleeding

Secondary amenorrhea

Dysmenorrhea

Premenstrual syndrome

As part of hormone replacement therapy (HRT)

Dosage

Adults

Threatened miscarriage: 40 mg initially, then 10 mg every 8 hours until symptoms subside. Habitual miscarriage: 10 mg twice daily until the 20th week of pregnancy. Endometriosis: 10 mg 2-3 times daily from day 5 to day 25 of the cycle, or continuously. HRT: 10-20 mg daily for 14 days of a 28-day cycle, or continuously with estrogen.

Elderly

No specific dose adjustment generally required, but caution with hepatic/renal impairment.

Renal_impairment

No specific dose adjustment guidance, but caution advised.

How to Take

To be taken orally, with or without food. Follow the physician's instructions regarding timing, especially in relation to the menstrual cycle for specific indications.

Mechanism of Action

Dydrogesterone acts directly on the uterus, mimicking the effects of natural progesterone. It binds to progesterone receptors, promoting the development of a secretory endometrium in estrogen-primed uteri. It also inhibits estrogen-induced endometrial proliferation.

Pharmacokinetics

Onset

Effects seen within hours for acute conditions like uterine bleeding; longer for chronic conditions.

Excretion

Primarily via urine (about 60%), some via feces. Eliminated as conjugates of its metabolites.

Half life

Parent drug: 5-14 hours. Main active metabolite (20α-dihydrodydrogesterone, DHD): 14-34 hours.

Absorption

Rapidly absorbed after oral administration, peak plasma levels within 0.5-2.5 hours. Bioavailability approximately 28%.

Metabolism

Extensively metabolized in the liver, primarily by 6-hydroxylation, into DHD, which is also active.

Side Effects

Contraindications

Known hypersensitivity to dydrogesterone or any excipients
Undiagnosed vaginal bleeding
Known or suspected progestogen-dependent tumour
Severe hepatic disorders

Drug Interactions

Ritonavir, Nelfinavir

May increase dydrogesterone levels.

Enzyme Inducers (e.g., Phenobarbital, Phenytoin, Rifampicin, Carbamazepine, St. John's Wort)

May decrease dydrogesterone levels and efficacy.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Overdose symptoms are generally mild, such as nausea, vomiting, dizziness, and drowsiness. Treatment is symptomatic and supportive. There is no specific antidote.

Pregnancy & Lactation

Pregnancy: Dydrogesterone is indicated for use in pregnancy in cases of threatened or habitual miscarriage under medical supervision. Lactation: Dydrogesterone is excreted in breast milk and is generally not recommended during breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip3 strips per box

Shelf Life

2-3 years from manufacturing date

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

Clinical Trials

Extensive clinical trials have established the efficacy and safety of Dydrogesterone for its approved indications.

Lab Monitoring

Regular gynecological check-ups are recommended, especially if used as part of hormone replacement therapy. No specific routine lab monitoring for dydrogesterone itself.

Doctor Notes

Consider potential for increased risk of thromboembolic events with progestogens, especially in patients with pre-existing risk factors.
Monitor liver function in patients with pre-existing hepatic disease or during long-term therapy.
Dydrogesterone does not inhibit ovulation at therapeutic doses and is not a contraceptive.

Patient Guidelines

Take as prescribed by your doctor.
Do not stop taking the medicine without consulting your doctor, even if you feel better.
Report any unusual vaginal bleeding or severe side effects to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.