For IV administration, reconstitute with sterile water for injection and inject slowly over 3-5 minutes, or administer as an infusion over 30-60 minutes. For IM administration, reconstitute with sterile water for injection and inject deeply into a large muscle.

Cefuroxime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes.

• •Known hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation.
• •History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems).

Store dry powder vials below 30°C, protected from light and moisture. Reconstituted solution should be used immediately or stored for a specified period (e.g., 24 hours at room temperature or 48 hours refrigerated) as per manufacturer guidelines.

Symptoms of overdose include convulsions, encephalopathy, and neuromuscular excitability. Management is supportive, and hemodialysis may be used to remove cefuroxime from the blood.

Pregnancy Category B. Cefuroxime crosses the placenta but generally considered safe. Use during pregnancy only if clearly needed. Excreted in breast milk in small quantities; caution should be exercised when administering to a nursing woman.