Furocef
Generic Name
Cefuroxime Axetil
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| furocef 125 mg suspension | ৳ 225.00 | N/A |
Description
Overview of the medicine
Furocef 125 mg Suspension is an antibiotic used to treat a wide variety of bacterial infections. It contains Cefuroxime Axetil, which belongs to a group of medicines called cephalosporins.
Uses & Indications
Dosage
Adults
Adults: For mild to moderate infections, 250 mg twice daily. For severe infections, 500 mg twice daily. (Note: Suspension typically for children, adults may need higher volumes or tablet form).
Elderly
Similar to adults, but dosage adjustment may be needed for reduced renal function.
Children
Children 3 months to 12 years: 125 mg (5 ml) twice daily for most infections. For otitis media or more severe infections, 250 mg (10 ml) twice daily. Dosing is often based on weight (e.g., 10-15 mg/kg twice daily).
Renal_impairment
Dose adjustment required based on creatinine clearance. For CrCl < 20 ml/min, one dose every 24 hours.
How to Take
Administer orally, preferably with food, for optimal absorption. Shake the suspension well before each use. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Cefuroxime Axetil works by inhibiting the synthesis of bacterial cell walls, leading to bacterial cell death (bactericidal action). It is active against a broad spectrum of Gram-positive and Gram-negative bacteria.
Pharmacokinetics
Onset
Peak plasma concentrations reached approximately 2-3 hours after oral administration.
Excretion
Excreted unchanged in the urine, primarily via glomerular filtration and tubular secretion.
Half life
Approximately 1.2 to 1.5 hours.
Absorption
Well absorbed from the gastrointestinal tract, especially when taken with food. Hydrolyzed to cefuroxime in the intestinal mucosa and blood.
Metabolism
Not significantly metabolized; hydrolyzed to active cefuroxime.
Side Effects
Contraindications
- •Known hypersensitivity to cefuroxime, other cephalosporins, or to any component of the formulation.
- •History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems).
Drug Interactions
Probenecid
Increases cefuroxime plasma levels, prolonging its effect.
Oral Contraceptives
May reduce the efficacy of estrogen-containing oral contraceptives.
Aminoglycosides / Loop Diuretics
Increased risk of nephrotoxicity when co-administered with potentially nephrotoxic drugs.
Storage
Store unreconstituted powder below 30°C in a dry place, away from light. Store reconstituted suspension in a refrigerator (2-8°C) and discard after 7-10 days.
Overdose
Symptoms of overdose include convulsions, nausea, vomiting, and diarrhea. Management is supportive. Hemodialysis and peritoneal dialysis may be helpful in removing the drug from the system.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. Use during pregnancy only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: 2-3 years. Reconstituted suspension: Typically 7-10 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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