Medicine Information

Hi-Floxin

Name: Hi-Floxin
Brand: Hi-Floxin
Rating: 4.5 (117 reviews)

Suspension200 mg/5 mlQuinolonesATC: J01MA01

Generic Name

Ofloxacin

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
hi floxin 200 mg suspension	N/A	N/A

Description

Overview of the medicine

Ofloxacin is a synthetic broad-spectrum antibacterial agent belonging to the fluoroquinolone class. It is effective against a wide range of gram-positive and gram-negative bacteria, used to treat various bacterial infections.

Uses & Indications

Urinary tract infections (UTIs)

Respiratory tract infections (RTIs)

Skin and soft tissue infections

Sexually transmitted diseases (STDs)

Prostatitis

Dosage

Adults

Typical dosage for adults is 200 mg to 400 mg twice daily, adjusted based on infection type and severity. For suspension, this translates to 5-10 ml twice daily.

Elderly

Dosage adjustment may be necessary for elderly patients, particularly those with impaired renal function.

Renal_impairment

Dosage should be reduced in patients with renal impairment based on creatinine clearance.

How to Take

For oral administration. Shake the suspension well before use. Can be taken with or without food. Ensure adequate hydration during treatment.

Mechanism of Action

Ofloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.

Pharmacokinetics

Onset

Within 1-2 hours of oral administration.

Excretion

Primarily renal, with 65-80% of the unchanged drug excreted in urine.

Half life

4-6 hours.

Absorption

Rapid and well absorbed orally, with a bioavailability of approximately 98%. Peak plasma concentrations are achieved within 1-2 hours.

Metabolism

Minimally metabolized in the liver, with less than 10% undergoing hepatic metabolism.

Side Effects

Contraindications

Hypersensitivity to Ofloxacin or any other fluoroquinolone
History of tendon disorders related to quinolone administration
Epilepsy or other seizure disorders

Drug Interactions

Warfarin

May enhance anticoagulant effects, leading to an increased risk of bleeding. Monitor INR closely.

Cimetidine, Cyclosporine

May alter Ofloxacin metabolism or elimination, requiring dose adjustments.

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

May increase CNS stimulation and the risk of seizures when co-administered with fluoroquinolones.

Antacids containing magnesium or aluminum, iron, and zinc supplements

Can significantly reduce Ofloxacin absorption. Administer at least 2 hours before or after Ofloxacin.

Storage

Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage and supportive care are recommended. Maintain adequate hydration. Symptoms may include CNS disturbances (e.g., confusion, seizures), gastrointestinal upset (e.g., nausea, vomiting).

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ofloxacin is excreted into breast milk and therefore not recommended during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 ml bottle60 ml bottle100 ml bottle

Shelf Life

Typically 24 to 36 months when stored as recommended.

Availability

Available in retail pharmacies and hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Patent Expired

WHO Essential Medicine

Yes

Clinical Trials

Ofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety profile across various bacterial infections. Further post-marketing surveillance continues to monitor for rare adverse effects.

Lab Monitoring

Renal function tests (creatinine clearance)
Liver function tests
Complete blood count
Blood glucose levels (especially in diabetic patients)
INR (in patients taking warfarin)

Doctor Notes

Counsel patients to complete the entire course of therapy, even if symptoms improve, to prevent the development of antibiotic resistance.
Monitor patients for signs and symptoms of tendinitis, peripheral neuropathy, and central nervous system effects. Discontinue the drug immediately if these adverse reactions occur.
Adjust dosage in patients with renal impairment based on creatinine clearance to prevent accumulation and toxicity.

Patient Guidelines

Complete the full prescribed course of treatment, even if symptoms improve, to prevent the development of antibiotic resistance.
Avoid excessive exposure to direct sunlight or artificial UV light during treatment, and use protective clothing/sunscreen.
Report any tendon pain, numbness, tingling, severe diarrhea, or sudden vision changes to your doctor immediately.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

This medicine may cause dizziness, lightheadedness, or visual disturbances. Patients should be cautious when driving or operating machinery until they know how Ofloxacin affects them.

Lifestyle Advice

Stay well-hydrated throughout the treatment period by drinking plenty of fluids.
Avoid excessive alcohol consumption as it may worsen dizziness or other CNS side effects.
Maintain a balanced diet and consult your doctor or pharmacist about food interactions.