Medicine Information

Leflox-TS

Name: Leflox-TS
Brand: Leflox-TS
Rating: 4.5 (117 reviews)

Eye Drop0.15% w/vOphthalmic Anti-infectivesATC: S01AE05

Generic Name

Levofloxacin

Manufacturer

Aron Pharma Limited

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
leflox ts 15 eye drop	৳ 128.00	N/A

Description

Overview of the medicine

Leflox-TS 0.15% Eye Drop is an antibiotic medicine containing Levofloxacin, used to treat bacterial infections of the eye, such as bacterial conjunctivitis and corneal ulcers. It works by stopping the growth of the causative bacteria.

Uses & Indications

Treatment of bacterial conjunctivitis caused by susceptible strains of bacteria.

Treatment of bacterial corneal ulcers caused by susceptible strains of bacteria.

Other superficial ocular bacterial infections.

Dosage

Adults

Bacterial Conjunctivitis: Instill 1-2 drops into the affected eye(s) every 2 hours while awake, up to 8 times a day for the first 2 days, then 1-2 drops every 4 hours while awake, up to 4 times a day for the next 5 days. Corneal Ulcers: Consult physician for specific regimen, typically more frequent initial dosing.

Elderly

No specific dose adjustment is generally required for ophthalmic use.

Renal_impairment

No specific dose adjustment required for ophthalmic use due to minimal systemic absorption.

How to Take

For ophthalmic use only. Tilt head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. Avoid touching the dropper tip to the eye or any other surface to prevent contamination.

Mechanism of Action

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.

Pharmacokinetics

Onset

Rapid onset of action at the site of infection, typically within minutes to hours.

Excretion

Mainly renal excretion for any systemically absorbed drug.

Half life

Systemic half-life is approximately 6-8 hours, but ocular kinetics are different with sustained levels in tear film.

Absorption

Minimal systemic absorption occurs after ocular administration, resulting in very low plasma concentrations.

Metabolism

Minimally metabolized; primarily excreted unchanged if systemically absorbed.

Side Effects

Contraindications

Hypersensitivity to levofloxacin, other quinolones, or any component of the formulation.
Viral or fungal eye infections.

Drug Interactions

Other ophthalmic medications

If using other eye drops, wait at least 5 minutes between applications. Ophthalmic ointments should be administered last.

Storage

Store at room temperature (below 30°C). Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Ophthalmic overdose is unlikely to cause systemic toxicity. If excess solution is instilled, it may be flushed from the eye with lukewarm water. If accidentally ingested, seek medical advice.

Pregnancy & Lactation

Use during pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks to the fetus or infant. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 ml bottle10 ml bottle

Shelf Life

24 months (unopened). Discard any remaining solution 28 days after opening.

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of levofloxacin ophthalmic solution in treating bacterial conjunctivitis and corneal ulcers.

Lab Monitoring

No specific routine lab monitoring is required for ophthalmic use of levofloxacin.

Doctor Notes

Educate patients on proper eye drop instillation technique to maximize efficacy and minimize contamination.
Advise patients to avoid contact lens wear during the course of treatment.
Monitor for signs of hypersensitivity reactions, especially with a history of quinolone allergy.

Patient Guidelines

Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Do not wear contact lenses during treatment for bacterial eye infections.
Avoid touching the dropper tip to any surface, including your eye, to prevent contamination.
If you experience severe eye pain, vision changes, or worsening redness, consult your doctor immediately.

Missed Dose Advice

If a dose is missed, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.