Osteo-D
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| osteo d 1000 iu chewable tablet | ৳ 6.00 | ৳ 84.00 |
Description
Overview of the medicine
Osteo-D 1000 IU Chewable Tablet contains Cholecalciferol (Vitamin D3) and is primarily used for the prevention and treatment of vitamin D deficiency and to support overall bone health. It plays a vital role in calcium and phosphate absorption and metabolism.
Uses & Indications
Dosage
Adults
For maintenance, 1000 IU (1 tablet) daily or as directed by physician. For deficiency, higher doses may be prescribed.
Elderly
Same as adults, or adjust based on physician's advice considering potential underlying conditions.
Renal_impairment
Use with caution. Doses may need adjustment. Close monitoring of serum calcium and phosphate levels is recommended.
How to Take
The tablet should be thoroughly chewed before swallowing. It can be taken with or without food. Taking it with a fatty meal may enhance absorption.
Mechanism of Action
Cholecalciferol (Vitamin D3) is biologically inactive and is converted in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol), its active form. Calcitriol enhances intestinal absorption of calcium and phosphate, stimulates bone mineralization, and regulates calcium and phosphate homeostasis.
Pharmacokinetics
Onset
Days to weeks for significant clinical effect.
Excretion
Primarily via bile into feces, a small amount renally.
Half life
Cholecalciferol: ~15-20 days; 25(OH)D (calcifediol): ~2-3 weeks.
Absorption
Well absorbed from the small intestine in the presence of bile salts; fat-soluble.
Metabolism
Hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol), then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol).
Side Effects
Contraindications
- Hypercalcaemia (abnormally high levels of calcium in the blood).
- Hypervitaminosis D (excessive amounts of vitamin D in the body).
- Severe renal impairment with hyperphosphataemia (high phosphate levels).
- Nephrolithiasis (kidney stones) or nephrocalcinosis.
Drug Interactions
Mineral oil
May reduce vitamin D absorption.
Corticosteroids
May reduce the effect of vitamin D.
Thiazide diuretics
May increase the risk of hypercalcaemia.
Phenytoin, Barbiturates
May increase vitamin D metabolism, reducing its effects.
Cholestyramine, Orlistat
May impair the absorption of vitamin D.
Cardiac glycosides (e.g., Digoxin)
Increased risk of cardiac arrhythmias if hypercalcaemia occurs.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcaemia (nausea, vomiting, weakness, thirst, polyuria, constipation, anorexia). Management involves discontinuing vitamin D, reducing calcium intake, hydration, and medical supervision. In severe cases, corticosteroids may be administered.
Pregnancy & Lactation
Generally considered safe in recommended doses during pregnancy and lactation. However, high doses should be avoided, and medical advice should be sought before use.
Side Effects
Contraindications
- Hypercalcaemia (abnormally high levels of calcium in the blood).
- Hypervitaminosis D (excessive amounts of vitamin D in the body).
- Severe renal impairment with hyperphosphataemia (high phosphate levels).
- Nephrolithiasis (kidney stones) or nephrocalcinosis.
Drug Interactions
Mineral oil
May reduce vitamin D absorption.
Corticosteroids
May reduce the effect of vitamin D.
Thiazide diuretics
May increase the risk of hypercalcaemia.
Phenytoin, Barbiturates
May increase vitamin D metabolism, reducing its effects.
Cholestyramine, Orlistat
May impair the absorption of vitamin D.
Cardiac glycosides (e.g., Digoxin)
Increased risk of cardiac arrhythmias if hypercalcaemia occurs.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcaemia (nausea, vomiting, weakness, thirst, polyuria, constipation, anorexia). Management involves discontinuing vitamin D, reducing calcium intake, hydration, and medical supervision. In severe cases, corticosteroids may be administered.
Pregnancy & Lactation
Generally considered safe in recommended doses during pregnancy and lactation. However, high doses should be avoided, and medical advice should be sought before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Drugstores
Approval Status
Approved by regulatory authorities
Patent Status
Expired
Clinical Trials
Numerous clinical trials and studies have demonstrated the efficacy of Cholecalciferol in preventing and treating vitamin D deficiency, improving bone mineral density, and reducing fracture risk.
Lab Monitoring
- Serum 25(OH)D levels (to assess vitamin D status).
- Serum calcium levels.
- Serum phosphate levels.
- Renal function (e.g., creatinine, BUN) in patients with kidney impairment.
Doctor Notes
- Assess patient's baseline Vitamin D status (25(OH)D) before initiating therapy, especially for deficiency correction.
- Monitor serum calcium and phosphate levels periodically, particularly in patients with pre-existing renal impairment or those concomitantly receiving cardiac glycosides.
- Educate patients on dietary sources of Vitamin D and calcium, and the importance of balanced nutrition.
- Caution against self-medication with high doses without medical supervision due to the risk of hypercalcaemia.
Patient Guidelines
- Do not exceed the recommended daily dose unless advised by a healthcare professional.
- Chew the tablet completely before swallowing to ensure proper absorption.
- Inform your doctor about all other medications, vitamins, and herbal supplements you are taking.
- Seek medical attention if you experience symptoms of hypercalcaemia.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cholecalciferol is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D sources.
- Engage in regular weight-bearing exercises to support bone health.
- Safe sun exposure (10-15 minutes, 2-3 times a week) can help the body produce vitamin D, but consult your doctor.
- Avoid smoking and excessive alcohol consumption, which can negatively impact bone density.
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