Osteo-D
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| osteo d 2000 iu chewable tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Osteo-D 2000 IU Chewable Tablet contains Cholecalciferol (Vitamin D3) and is used to treat and prevent Vitamin D deficiency and associated conditions like osteoporosis and osteomalacia. It supports calcium absorption and bone health.
Uses & Indications
Dosage
Adults
For Vitamin D deficiency, typically 2000 IU daily. Doses may vary based on serum 25(OH)D levels and clinical condition, as advised by a physician. For maintenance, 800-2000 IU daily.
Elderly
Similar to adult dosage, but may require closer monitoring due to potential underlying conditions and drug interactions. Daily intake of 800-2000 IU is often recommended.
Renal_impairment
Use with caution. High doses may lead to hypercalcemia. Monitoring of calcium and phosphate levels is crucial. May require activated forms of Vitamin D if renal impairment is severe.
How to Take
Chew the tablet completely before swallowing, preferably with a meal to enhance absorption. Do not swallow whole.
Mechanism of Action
Cholecalciferol (Vitamin D3) is a precursor that is metabolized in the liver and kidneys to calcitriol, the active form of Vitamin D. Calcitriol regulates calcium and phosphate homeostasis by promoting their absorption in the intestine, enhancing bone mineralization, and affecting renal tubular reabsorption.
Pharmacokinetics
Onset
Weeks to months for significant changes in serum 25(OH)D levels.
Excretion
Mainly excreted in bile and feces, with a small amount in urine.
Half life
Initial half-life of Cholecalciferol is 24 hours, but the active metabolite 25(OH)D3 has a half-life of approximately 2-3 weeks, and 1,25(OH)2D3 (calcitriol) has a half-life of 4-6 hours.
Absorption
Readily absorbed from the gastrointestinal tract, especially in the presence of bile salts and dietary fats.
Metabolism
Hydroxylated in the liver to 25-hydroxycholecalciferol (calcidiol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any components of the tablet.
- Hypercalcemia (high levels of calcium in the blood).
- Hypervitaminosis D (excessively high levels of Vitamin D).
- Severe renal impairment (unless managed with activated Vitamin D forms).
Drug Interactions
Corticosteroids
May reduce the effects of Vitamin D.
Thiazide diuretics
May increase the risk of hypercalcemia.
Cholestyramine, mineral oil, orlistat
May reduce absorption of Vitamin D.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase Vitamin D metabolism and reduce its effectiveness.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia, nausea, vomiting, constipation, polyuria, polydipsia, and muscle weakness. Treatment involves discontinuing Vitamin D, hydrating the patient, and managing hypercalcemia.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. However, doses should be carefully monitored to avoid hypervitaminosis D, which can be harmful to the fetus or infant. Consult a doctor for appropriate dosage.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any components of the tablet.
- Hypercalcemia (high levels of calcium in the blood).
- Hypervitaminosis D (excessively high levels of Vitamin D).
- Severe renal impairment (unless managed with activated Vitamin D forms).
Drug Interactions
Corticosteroids
May reduce the effects of Vitamin D.
Thiazide diuretics
May increase the risk of hypercalcemia.
Cholestyramine, mineral oil, orlistat
May reduce absorption of Vitamin D.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase Vitamin D metabolism and reduce its effectiveness.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia, nausea, vomiting, constipation, polyuria, polydipsia, and muscle weakness. Treatment involves discontinuing Vitamin D, hydrating the patient, and managing hypercalcemia.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. However, doses should be carefully monitored to avoid hypervitaminosis D, which can be harmful to the fetus or infant. Consult a doctor for appropriate dosage.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials support the efficacy and safety of Cholecalciferol in preventing and treating Vitamin D deficiency and associated bone diseases.
Lab Monitoring
- Serum 25(OH)D levels (to assess Vitamin D status)
- Serum calcium levels
- Serum phosphate levels
- Renal function tests
Doctor Notes
- Advise patients to maintain adequate hydration.
- Emphasize the importance of dietary calcium intake.
- Regularly assess patient's Vitamin D status and calcium levels.
Patient Guidelines
- Take this medicine as directed by your doctor or pharmacist.
- Chew the tablet completely before swallowing.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications and supplements you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Osteo-D is unlikely to affect your ability to drive or operate machinery.
Lifestyle Advice
- Ensure adequate sunlight exposure.
- Maintain a balanced diet rich in calcium and Vitamin D.
- Regular exercise for bone health.
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