Osteo-D
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Apothecary Labs
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| osteo d 200 iu pediatric drop | ৳ 75.00 | N/A |
Description
Overview of the medicine
Osteo-D 200 IU Pediatric Drop is an oral vitamin D3 (Cholecalciferol) supplement used to prevent and treat vitamin D deficiency in infants and young children. Vitamin D is crucial for bone health, calcium absorption, and immune function.
Uses & Indications
Dosage
Adults
Not applicable for this pediatric formulation. For pediatric patients: Infants (0-12 months): 1-2 drops (200-400 IU) daily. Children (1-10 years): 2-3 drops (400-600 IU) daily. Or as directed by physician.
Elderly
Not applicable for this pediatric formulation.
Renal_impairment
For pediatric patients with renal impairment, dose adjustment requires careful medical supervision.
How to Take
Administer orally, preferably with a meal to enhance absorption. Can be dropped directly into the child's mouth or mixed with milk, juice, or food.
Mechanism of Action
Cholecalciferol (Vitamin D3) is a precursor that is hydroxylated in the liver to 25-hydroxycholecalciferol (calcidiol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form of vitamin D. Calcitriol acts by binding to vitamin D receptors, regulating calcium and phosphate homeostasis, promoting intestinal absorption of calcium, and bone mineralization.
Pharmacokinetics
Onset
Therapeutic effects may take several days to weeks to manifest, as stores need to be replenished.
Excretion
Mainly excreted in bile and feces; small amounts in urine.
Half life
Plasma half-life of 25(OH)D3 (calcidiol) is approximately 15-30 days; the active form 1,25(OH)2D3 (calcitriol) has a half-life of 4-6 hours.
Absorption
Well absorbed from the gastrointestinal tract, especially in the presence of bile salts and dietary fat.
Metabolism
Metabolized in the liver to 25-hydroxycholecalciferol and then in the kidneys to 1,25-dihydroxycholecalciferol and other inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any components
- Hypercalcemia (high calcium levels)
- Hypervitaminosis D (vitamin D toxicity)
- Severe renal impairment with hyperphosphatemia
Drug Interactions
Corticosteroids
May impair vitamin D action.
Thiazide diuretics
May increase risk of hypercalcemia.
Phenytoin, Barbiturates
May accelerate vitamin D metabolism, reducing its effect.
Cardiac glycosides (e.g., Digoxin)
Increased risk of toxicity due to increased calcium levels.
Cholestyramine, Colestipol, Orlistat, mineral oil
May reduce absorption of vitamin D.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Do not freeze.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, polyuria, polydipsia), hypercalciuria, and renal impairment. Treatment involves discontinuing the supplement, hydrating, and managing hypercalcemia under medical supervision.
Pregnancy & Lactation
While essential, this pediatric formulation is not intended for pregnant or lactating women. Specific dosages for adults should be followed under medical advice.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any components
- Hypercalcemia (high calcium levels)
- Hypervitaminosis D (vitamin D toxicity)
- Severe renal impairment with hyperphosphatemia
Drug Interactions
Corticosteroids
May impair vitamin D action.
Thiazide diuretics
May increase risk of hypercalcemia.
Phenytoin, Barbiturates
May accelerate vitamin D metabolism, reducing its effect.
Cardiac glycosides (e.g., Digoxin)
Increased risk of toxicity due to increased calcium levels.
Cholestyramine, Colestipol, Orlistat, mineral oil
May reduce absorption of vitamin D.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Do not freeze.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, polyuria, polydipsia), hypercalciuria, and renal impairment. Treatment involves discontinuing the supplement, hydrating, and managing hypercalcemia under medical supervision.
Pregnancy & Lactation
While essential, this pediatric formulation is not intended for pregnant or lactating women. Specific dosages for adults should be followed under medical advice.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date when stored properly.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by regulatory authorities for vitamin D supplementation
Patent Status
Generic (Cholecalciferol is off-patent)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials support the efficacy of vitamin D supplementation in preventing and treating deficiency in pediatric populations, showing improvements in bone mineral density and reduction in rickets incidence.
Lab Monitoring
- Serum 25(OH)D levels (to assess vitamin D status)
- Serum calcium and phosphate levels (especially in long-term therapy or high doses)
- Urinary calcium (if hypercalciuria is suspected)
Doctor Notes
- Emphasize the importance of accurate dosing using the calibrated dropper.
- Educate parents on the signs of vitamin D deficiency and potential overdose symptoms.
- Advise regular follow-ups to monitor vitamin D status, especially in high-risk groups.
Patient Guidelines
- Follow dosage instructions carefully.
- Do not exceed the recommended dose without consulting a doctor.
- Store in a cool, dry place away from direct sunlight.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is close to the time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
None known; Cholecalciferol does not impair ability to drive or operate machinery.
Lifestyle Advice
- Encourage sunlight exposure (safe limits for children).
- Ensure a balanced diet rich in calcium and vitamin D.
- Regular physical activity for bone health.
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