Osteo-D
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Local Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| osteo d 200000 iu injectable solution oral im | ৳ 120.00 | N/A |
Description
Overview of the medicine
High-dose Vitamin D3 formulation used for the treatment of severe Vitamin D deficiency and related conditions like rickets and osteomalacia. It can be administered orally or as an intramuscular injection.
Uses & Indications
Dosage
Adults
For severe deficiency: 200,000 IU as a single dose, followed by maintenance doses, or as directed by physician. Dosage frequency depends on initial Vitamin D levels and patient response.
Elderly
Similar to adults, but caution should be exercised in those with renal impairment and concomitant medications. Monitor Vitamin D and calcium levels closely.
Renal_impairment
Use with caution. In severe renal impairment, active forms of Vitamin D (e.g., calcitriol) may be preferred. Dosage adjustment and monitoring of calcium/phosphate levels are crucial.
How to Take
This solution can be administered orally (swallowed directly or mixed with food/drink) or as a deep intramuscular injection by a healthcare professional.
Mechanism of Action
Cholecalciferol (Vitamin D3) is a fat-soluble vitamin that helps the body absorb calcium and phosphate from the gut, facilitating normal bone mineralization and growth. It plays a crucial role in maintaining calcium and phosphate homeostasis and bone health.
Pharmacokinetics
Onset
Clinical effects may take several days to weeks to become evident, as it requires metabolism to active forms.
Excretion
Primarily excreted via bile into the feces, with a small amount excreted in urine.
Half life
Cholecalciferol itself has a plasma half-life of a few hours. The primary circulating metabolite, 25-hydroxyvitamin D (calcifediol), has a half-life of approximately 15 days.
Absorption
Readily absorbed from the small intestine (oral) or rapidly enters systemic circulation (intramuscular). Absorption is enhanced in the presence of dietary fat.
Metabolism
Initially hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol), then further hydroxylated in the kidneys to the active form, 1,25-dihydroxyvitamin D (calcitriol).
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any component of the formulation
- Hypercalcemia (high levels of calcium in the blood)
- Hypervitaminosis D (excessive vitamin D levels)
- Severe renal impairment with hyperphosphatemia (high phosphate levels)
Drug Interactions
Corticosteroids
May reduce the effect of vitamin D.
Thiazide Diuretics
May increase the risk of hypercalcemia.
Digitalis Glycosides
May increase the risk of arrhythmias due to hypercalcemia.
Phenytoin/Barbiturates
May accelerate vitamin D metabolism, reducing its effectiveness.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose can lead to hypercalcemia, causing symptoms such as nausea, vomiting, constipation, weakness, polyuria, polydipsia, and in severe cases, kidney damage and cardiac arrhythmias. Management involves discontinuing the drug, hydration, and symptomatic treatment for hypercalcemia.
Pregnancy & Lactation
Generally considered safe at recommended doses during pregnancy and lactation. However, high doses should be avoided due to potential risks of hypercalcemia in the mother and fetus/infant. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any component of the formulation
- Hypercalcemia (high levels of calcium in the blood)
- Hypervitaminosis D (excessive vitamin D levels)
- Severe renal impairment with hyperphosphatemia (high phosphate levels)
Drug Interactions
Corticosteroids
May reduce the effect of vitamin D.
Thiazide Diuretics
May increase the risk of hypercalcemia.
Digitalis Glycosides
May increase the risk of arrhythmias due to hypercalcemia.
Phenytoin/Barbiturates
May accelerate vitamin D metabolism, reducing its effectiveness.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose can lead to hypercalcemia, causing symptoms such as nausea, vomiting, constipation, weakness, polyuria, polydipsia, and in severe cases, kidney damage and cardiac arrhythmias. Management involves discontinuing the drug, hydration, and symptomatic treatment for hypercalcemia.
Pregnancy & Lactation
Generally considered safe at recommended doses during pregnancy and lactation. However, high doses should be avoided due to potential risks of hypercalcemia in the mother and fetus/infant. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, consult product specific packaging for exact details.
Availability
Pharmacies and Hospitals
Approval Status
Generally approved
Patent Status
Generic
Clinical Trials
Extensive clinical trials and research have established the efficacy and safety of Cholecalciferol in treating Vitamin D deficiency and related bone disorders.
Lab Monitoring
- Serum 25-hydroxyvitamin D levels (to assess vitamin D status)
- Serum calcium levels (to monitor for hypercalcemia)
- Serum phosphate levels
- Parathyroid hormone (PTH) levels
- Renal function tests (e.g., creatinine, BUN)
Doctor Notes
- Crucial to assess baseline Vitamin D, calcium, and phosphate levels before initiating therapy.
- Monitor serum calcium and 25(OH)D levels periodically during treatment to prevent hypercalcemia and ensure therapeutic efficacy.
- Educate patients on the symptoms of hypercalcemia and instruct them to report any such symptoms promptly.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose.
- Report any symptoms of hypercalcemia (e.g., nausea, vomiting, excessive thirst or urination, muscle weakness) to your doctor immediately.
- Ensure adequate intake of calcium through diet or supplements as advised by your healthcare provider.
Missed Dose Advice
Since this is typically an infrequent, high-dose medication, if a scheduled dose is missed, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cholecalciferol is not known to directly affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or extreme weakness, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and Vitamin D.
- Engage in regular, moderate sunlight exposure (if possible and appropriate).
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