Osteo-D
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
XYZ Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| osteo d 20000 iu capsule | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Cholecalciferol (Vitamin D3) is an essential fat-soluble vitamin crucial for calcium and phosphate metabolism, bone health, and immune function.
Uses & Indications
Dosage
Adults
For severe Vitamin D deficiency: 20000 IU weekly for 7 weeks, followed by a maintenance dose as directed by a physician. For maintenance: typically 800-2000 IU daily (adjust based on serum 25(OH)D levels).
Elderly
Similar to adult dosage, but close monitoring of serum calcium and vitamin D levels is recommended, especially in patients with renal impairment or those taking other medications.
Renal_impairment
Use with caution. Monitor serum calcium, phosphate, and 25(OH)D levels frequently. Dose adjustment may be necessary based on severity and individual response. Consult a nephrologist.
How to Take
Take orally with water, preferably with the largest meal of the day to enhance absorption. Do not crush or chew the capsule.
Mechanism of Action
Cholecalciferol is converted in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol), its active form. Calcitriol enhances intestinal absorption of calcium and phosphate, promotes bone mineralization, and regulates parathyroid hormone secretion.
Pharmacokinetics
Onset
Therapeutic effects typically begin within days to weeks, with full stabilization of vitamin D levels taking longer.
Excretion
Mainly excreted in bile and feces, with a small amount excreted in urine.
Half life
Parent compound (cholecalciferol) has a half-life of approximately 24 hours. The main circulating metabolite, 25(OH)D, has a half-life of about 15 days.
Absorption
Well absorbed from the gastrointestinal tract, especially when taken with fatty meals. Requires bile salts for optimal absorption.
Metabolism
Initially hydroxylated in the liver to 25-hydroxyvitamin D3 (calcifediol), then further hydroxylated in the kidneys to 1,25-dihydroxyvitamin D3 (calcitriol), the active form.
Side Effects
Contraindications
- Hypersensitivity to cholecalciferol or any components of the formulation
- Hypercalcemia (high levels of calcium in the blood)
- Hypervitaminosis D (excessive levels of Vitamin D)
- Severe renal impairment with hyperphosphatemia
Drug Interactions
Corticosteroids
May reduce the effects of Vitamin D by interfering with calcium absorption and metabolism.
Thiazide diuretics
May increase the risk of hypercalcemia by reducing calcium excretion.
Cardiac glycosides (e.g., digoxin)
Hypercalcemia induced by Vitamin D may potentiate the effects and toxicity of cardiac glycosides.
Cholestyramine, Colestipol, Mineral oil
May reduce the absorption of Vitamin D from the gastrointestinal tract.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase the metabolism of Vitamin D, potentially leading to lower 25(OH)D levels.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypervitaminosis D) include hypercalcemia with symptoms like nausea, vomiting, constipation, polyuria, polydipsia, weakness, headache, and in severe cases, kidney damage and cardiac arrhythmias. Management involves discontinuing Vitamin D, hydration, and medical support.
Pregnancy & Lactation
Cholecalciferol is generally safe during pregnancy and lactation at recommended doses. High doses should only be used if the potential benefit outweighs the potential risk and under strict medical supervision. Consult your doctor before use.
Side Effects
Contraindications
- Hypersensitivity to cholecalciferol or any components of the formulation
- Hypercalcemia (high levels of calcium in the blood)
- Hypervitaminosis D (excessive levels of Vitamin D)
- Severe renal impairment with hyperphosphatemia
Drug Interactions
Corticosteroids
May reduce the effects of Vitamin D by interfering with calcium absorption and metabolism.
Thiazide diuretics
May increase the risk of hypercalcemia by reducing calcium excretion.
Cardiac glycosides (e.g., digoxin)
Hypercalcemia induced by Vitamin D may potentiate the effects and toxicity of cardiac glycosides.
Cholestyramine, Colestipol, Mineral oil
May reduce the absorption of Vitamin D from the gastrointestinal tract.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase the metabolism of Vitamin D, potentially leading to lower 25(OH)D levels.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypervitaminosis D) include hypercalcemia with symptoms like nausea, vomiting, constipation, polyuria, polydipsia, weakness, headache, and in severe cases, kidney damage and cardiac arrhythmias. Management involves discontinuing Vitamin D, hydration, and medical support.
Pregnancy & Lactation
Cholecalciferol is generally safe during pregnancy and lactation at recommended doses. High doses should only be used if the potential benefit outweighs the potential risk and under strict medical supervision. Consult your doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, depending on storage conditions.
Availability
Pharmacies, Hospitals
Approval Status
Generally approved
Patent Status
Generic
Clinical Trials
Numerous clinical trials are ongoing to investigate the role of vitamin D in various health conditions beyond bone health, including immune disorders, cardiovascular disease, and certain cancers.
Lab Monitoring
- Serum 25(OH)D levels (to assess vitamin D status)
- Serum calcium levels (to monitor for hypercalcemia)
- Serum phosphate levels
- Parathyroid hormone (PTH) levels (in certain conditions)
- Urine calcium excretion (in some patients)
Doctor Notes
- Always assess baseline serum 25(OH)D levels before initiating high-dose cholecalciferol therapy.
- Monitor serum calcium, phosphate, and parathyroid hormone (PTH) levels periodically, especially in patients with renal impairment or those on concomitant medications.
- Educate patients on symptoms of hypercalcemia and the importance of adherence to prescribed dosing regimens.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any symptoms of hypercalcemia (e.g., persistent nausea, vomiting, unusual tiredness) immediately to your doctor.
- Do not exceed the recommended dose without consulting your physician.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cholecalciferol is not known to impair the ability to drive or operate machinery. No special precautions are necessary.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D.
- Engage in regular weight-bearing exercise for bone health.
- Moderate sun exposure can help with natural vitamin D synthesis, but be mindful of skin protection.
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