Medicine Information

Renova

Name: Renova
Brand: Renova

Cream0.05% CreamRetinoidsATC: D10AD01

Generic Name

Tretinoin

Manufacturer

Ortho Dermatologics (Bausch Health)

Country

USA

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
renova 120 mg syrup	৳ 35.00	N/A
renova 500 mg tablet	৳ 1.20	৳ 12.00
renova 10 mg injection	৳ 138.00	N/A
renova 120 mg suspension	৳ 35.00	N/A
renova 60 mg suppository	৳ 3.51	N/A
renova 125 mg suppository	৳ 4.02	N/A
renova 250 mg suppository	৳ 5.02	N/A
renova 500 mg suppository	৳ 8.03	N/A
renova 80 mg pediatric drop	৳ 20.00	N/A

Description

Overview of the medicine

Renova (Tretinoin) cream is a topical retinoid primarily used to reduce fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin due to photoaging. It is also used for the treatment of acne vulgaris.

Uses & Indications

Fine wrinkles

Mottled hyperpigmentation

Tactile roughness of facial skin due to photoaging

Acne vulgaris

Dosage

Adults

Apply a pea-sized amount to the entire affected area of the face once daily in the evening, after washing and drying the skin. Gently massage into the skin.

Elderly

Same as adults, with careful monitoring for skin irritation.

Renal_impairment

No specific dosage adjustment needed for topical use.

How to Take

Apply to clean, dry skin. Wash your face with a mild cleanser and pat dry before application. Use once daily, typically at bedtime. Avoid applying near eyes, mouth, and nostrils. Allow 20-30 minutes after washing your face before applying to ensure skin is completely dry.

Mechanism of Action

Tretinoin works by binding to retinoid receptors (RARs and RXRs) in skin cells, influencing gene expression that normalizes cell differentiation, proliferation, and reduces inflammation. It promotes increased cell turnover, reduces the cohesion of follicular epithelial cells, and enhances the shedding of old cells.

Pharmacokinetics

Onset

Effects on acne can be seen within 2-3 weeks, but significant improvement for photoaging may take 3-6 months.

Excretion

If absorbed, excreted in urine and feces.

Half life

Systemic half-life is approximately 0.75 hours (if absorbed), but topical effects are sustained.

Absorption

Minimal systemic absorption after topical application. Approximately 1.6% to 5.4% is absorbed through the skin.

Metabolism

If absorbed, metabolized in the liver to inactive metabolites.

Side Effects

Contraindications

Pregnancy (Category C, but often avoided due to potential risks)
Hypersensitivity to tretinoin or any excipients
Severe sunburn or acutely inflamed skin

Drug Interactions

Photosensitizing agents

Increased risk of sunburn with other medications that increase sensitivity to sunlight (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines).

Storage

Store at room temperature (below 25°C), away from direct light and moisture. Do not freeze. Keep out of reach of children.

Overdose

Excessive topical application of tretinoin may result in marked redness, peeling, or discomfort. Systemic overdose is unlikely due to minimal absorption. Treatment should be symptomatic.

Pregnancy & Lactation

Tretinoin is generally contraindicated in pregnancy (Category C) due to potential teratogenic effects, especially with systemic exposure. Although topical absorption is minimal, it is advised to avoid use. For lactation, it is unknown if tretinoin is excreted in human milk; use with caution and only if clearly needed after consulting a doctor.

Side Effects

Contraindications

Pregnancy (Category C, but often avoided due to potential risks)
Hypersensitivity to tretinoin or any excipients
Severe sunburn or acutely inflamed skin

Drug Interactions

Photosensitizing agents

Increased risk of sunburn with other medications that increase sensitivity to sunlight (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines).

Storage

Store at room temperature (below 25°C), away from direct light and moisture. Do not freeze. Keep out of reach of children.

Overdose

Excessive topical application of tretinoin may result in marked redness, peeling, or discomfort. Systemic overdose is unlikely due to minimal absorption. Treatment should be symptomatic.

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

20g Cream30g Cream

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Pharmacies, drugstores

Approval Status

FDA approved

Patent Status

Patent expired, generic available

Clinical Trials

Extensive clinical trials have demonstrated tretinoin's efficacy in treating acne vulgaris and mitigating the signs of photoaging, including fine wrinkles and hyperpigmentation.

Lab Monitoring

No specific laboratory monitoring is typically required for topical tretinoin.

Doctor Notes

Emphasize patient education on proper application technique, starting with a lower frequency if irritation occurs. Stress the importance of daily sun protection. Advise patients that initial irritation (retinization) is common and usually subsides over time.
Regular follow-up is important to monitor progress and manage side effects.

Patient Guidelines

Always use sunscreen with an SPF of 15 or higher and protective clothing when outdoors.
Avoid excessive exposure to sunlight, sunlamps, or tanning booths.
Apply a pea-sized amount evenly to the face.
Use mild, non-medicated cleansers and moisturizers.
Do not wax treated areas.

Missed Dose Advice

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.