Medicine Information

Sefur

Name: Sefur
Brand: Sefur

Oral Suspension125 mg/5 mLSecond Generation CephalosporinsATC: J01DC02

Generic Name

Cefuroxime Axetil 125 mg Suspension

Manufacturer

Reputable Generic Manufacturer

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
sefur 125 mg suspension	৳ 225.00	N/A

Description

Overview of the medicine

Sefur 125 mg Suspension is an antibiotic from the cephalosporin class, used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and otitis media.

Uses & Indications

Upper and lower respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections (e.g., cystitis, pyelonephritis)

Skin and soft tissue infections (e.g., cellulitis, erysipelas)

Otitis media (middle ear infection)

Sinusitis

Early Lyme disease

Dosage

Adults

Dosage varies by infection. Typically 250 mg to 500 mg twice daily. For suspension, dosage is usually weight-based for children.

Elderly

Similar to adult dosage, but caution with renal impairment.

Renal_impairment

Dosage adjustment may be necessary in severe renal impairment (creatinine clearance <20 mL/min).

How to Take

For oral use. Administer with food to enhance absorption and reduce gastrointestinal discomfort. Shake the bottle well before each use. Use the provided measuring device for accurate dosing.

Mechanism of Action

Cefuroxime works by inhibiting the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall.

Pharmacokinetics

Onset

Peak plasma concentrations are generally achieved within 2-3 hours after oral administration.

Excretion

Excreted unchanged in the urine, primarily via glomerular filtration and tubular secretion. Approximately 50% of an administered dose is excreted within 12 hours.

Half life

Approximately 1 to 1.5 hours in adults with normal renal function.

Absorption

Well absorbed from the gastrointestinal tract after oral administration of cefuroxime axetil. Absorption is enhanced with food.

Metabolism

Cefuroxime axetil is rapidly hydrolyzed by esterases in the intestinal mucosa and blood to release cefuroxime into the circulation. It is not significantly metabolized in the liver.

Side Effects

Contraindications

Hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation.
History of severe hypersensitivity reactions (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins).

Drug Interactions

Probenecid

Concomitant administration of probenecid increases cefuroxime AUC (area under the curve) and prolongs its half-life.

Oral anticoagulants

May potentiate the anticoagulant effect. Close monitoring of INR is recommended.

Antacids/H2-receptor antagonists

May reduce the bioavailability of cefuroxime axetil. It is recommended to take cefuroxime axetil at least one hour before or two hours after antacids/H2-receptor antagonists.

Storage

Store dry powder below 30°C, protected from light and moisture. Keep reconstituted suspension refrigerated (2-8°C) and discard after 7-10 days.

Overdose

Symptoms of overdose include convulsions, encephalopathy, and other neurological effects. Treatment is symptomatic and supportive. Hemodialysis can be used to reduce serum cefuroxime levels.

Pregnancy & Lactation

Pregnancy Category B. Cefuroxime has been widely used in pregnant women without adverse effects. Small amounts are excreted in breast milk, generally considered compatible with breastfeeding. Consult a doctor.

Side Effects

Contraindications

Hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation.
History of severe hypersensitivity reactions (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins).

Drug Interactions

Probenecid

Concomitant administration of probenecid increases cefuroxime AUC (area under the curve) and prolongs its half-life.

Oral anticoagulants

May potentiate the anticoagulant effect. Close monitoring of INR is recommended.

Antacids/H2-receptor antagonists

May reduce the bioavailability of cefuroxime axetil. It is recommended to take cefuroxime axetil at least one hour before or two hours after antacids/H2-receptor antagonists.

Storage

Store dry powder below 30°C, protected from light and moisture. Keep reconstituted suspension refrigerated (2-8°C) and discard after 7-10 days.

Overdose

Symptoms of overdose include convulsions, encephalopathy, and other neurological effects. Treatment is symptomatic and supportive. Hemodialysis can be used to reduce serum cefuroxime levels.

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

50 mL bottle70 mL bottle100 mL bottle

Shelf Life

Typically 24-36 months for unopened dry powder. Reconstituted suspension usually stable for 7-10 days under refrigeration.

Availability

Pharmacies, Hospitals

Approval Status

Approved (e.g., FDA, DGDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Cefuroxime has undergone extensive clinical trials establishing its efficacy and safety for various bacterial infections since its introduction.

Lab Monitoring

Renal function tests (for prolonged therapy or in patients with renal impairment)
Complete blood count (for prolonged therapy)

Doctor Notes

Prescribe appropriately based on culture and sensitivity results where possible, or according to local guidelines.
Counsel patients on the importance of completing the full course of therapy to prevent resistance.
Advise parents/caregivers on proper reconstitution and administration of suspension.

Patient Guidelines

Complete the entire course of medication as prescribed, even if symptoms improve.
Take the medicine with food to enhance absorption and reduce stomach upset.
Shake the bottle well before each use and use the provided measuring cup or spoon.
Do not save unused medication for future infections.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.