Sefur

For intravenous (IV) administration, reconstitute the 1.5 gm vial with 15 mL of sterile water for injection, then dilute in 50-100 mL of compatible IV fluid and infuse slowly over 20-60 minutes. For intramuscular (IM) administration, reconstitute with 6 mL of sterile water for injection and inject deeply into a large muscle.

Cefuroxime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, preventing the final transpeptidation step of peptidoglycan synthesis.

• Known hypersensitivity to cefuroxime or any other cephalosporin antibiotics.
• History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems).

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Reconstituted solution should be used immediately or stored as per manufacturer's guidelines (e.g., refrigerated for up to 24 hours).

Symptoms of overdose may include convulsions, encephalopathy, and neuromuscular excitability. Management is supportive, including monitoring vital signs and renal function. Hemodialysis can remove cefuroxime from the body.

Pregnancy Category B. Cefuroxime crosses the placenta but generally considered safe. Use during pregnancy only if clearly needed. Excreted in small amounts in breast milk; use with caution in breastfeeding mothers.

• Known hypersensitivity to cefuroxime or any other cephalosporin antibiotics.
• History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems).

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Reconstituted solution should be used immediately or stored as per manufacturer's guidelines (e.g., refrigerated for up to 24 hours).

Symptoms of overdose may include convulsions, encephalopathy, and neuromuscular excitability. Management is supportive, including monitoring vital signs and renal function. Hemodialysis can remove cefuroxime from the body.

Pregnancy Category B. Cefuroxime crosses the placenta but generally considered safe. Use during pregnancy only if clearly needed. Excreted in small amounts in breast milk; use with caution in breastfeeding mothers.