Medicine Information

Sefur

Name: Sefur
Brand: Sefur

Tablet125 mgAntibiotics (Cephalosporin)ATC: J01DC02

Generic Name

Cefuroxime Axetil

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
sefur 125 mg tablet	৳ 15.10	৳ 90.60

Description

Overview of the medicine

Sefur 125 mg Tablet contains Cefuroxime Axetil, a second-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections including respiratory tract infections, ear infections, skin and soft tissue infections, and urinary tract infections.

Uses & Indications

Upper and lower respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections (e.g., cystitis, pyelonephritis)

Skin and soft tissue infections (e.g., cellulitis, impetigo)

Otitis media and sinusitis

Uncomplicated gonorrhea

Dosage

Adults

For mild to moderate infections: 125-250 mg twice daily. For severe infections (e.g., bronchitis, pneumonia): 250-500 mg twice daily (using higher strength tablets). For uncomplicated urinary tract infections: 125 mg twice daily.

Elderly

Same as adults, but dose adjustment may be necessary in case of renal impairment.

Renal_impairment

Dose adjustment is required based on creatinine clearance. For CrCl 10-29 mL/min, 125-250 mg once daily. For CrCl <10 mL/min, 125-250 mg every 48 hours.

How to Take

Take orally, preferably with food to enhance absorption and reduce gastrointestinal discomfort. Do not crush or chew the tablet; swallow it whole.

Mechanism of Action

Cefuroxime Axetil is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), thus preventing the cross-linking of peptidoglycan chains, which is essential for bacterial cell wall integrity and strength, leading to cell lysis and death.

Pharmacokinetics

Onset

Oral absorption peaks approximately 2-3 hours after administration with food.

Excretion

Excreted unchanged in the urine, primarily by glomerular filtration and tubular secretion.

Half life

Approximately 1 to 1.5 hours in adults with normal renal function.

Absorption

Cefuroxime axetil is well absorbed from the gastrointestinal tract and rapidly hydrolyzed by esterases to cefuroxime. Absorption is enhanced when administered with food.

Metabolism

Cefuroxime axetil is rapidly hydrolyzed in the intestinal mucosa and blood to the active moiety, cefuroxime. It is not significantly metabolized in the liver.

Side Effects

Contraindications

Known hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation
History of severe hypersensitivity reaction to any other beta-lactam antibiotic (e.g., penicillins)

Drug Interactions

Probenecid

Increases cefuroxime plasma concentrations and prolongs its duration of action by reducing renal tubular secretion.

Oral Contraceptives

May reduce the efficacy of oral contraceptives by altering gut flora; additional barrier contraception is advised.

Antacids/H2 blockers/PPIs

May decrease the bioavailability of cefuroxime axetil, leading to reduced absorption. It is recommended to administer cefuroxime axetil at least 2 hours before or 4 hours after antacids/H2 blockers.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include cerebral irritation leading to convulsions. Management is supportive and symptomatic; hemodialysis may be beneficial in cases of severe overdose.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. Cefuroxime is excreted in breast milk in small quantities; use with caution during lactation. Consult a doctor before use.

Side Effects

Contraindications

Known hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation
History of severe hypersensitivity reaction to any other beta-lactam antibiotic (e.g., penicillins)

Drug Interactions

Probenecid

Increases cefuroxime plasma concentrations and prolongs its duration of action by reducing renal tubular secretion.

Oral Contraceptives

May reduce the efficacy of oral contraceptives by altering gut flora; additional barrier contraception is advised.

Antacids/H2 blockers/PPIs

May decrease the bioavailability of cefuroxime axetil, leading to reduced absorption. It is recommended to administer cefuroxime axetil at least 2 hours before or 4 hours after antacids/H2 blockers.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include cerebral irritation leading to convulsions. Management is supportive and symptomatic; hemodialysis may be beneficial in cases of severe overdose.

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 tablets3 x 10 tablets

Shelf Life

24-36 months from manufacturing date

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory authorities

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of cefuroxime axetil for its approved indications. Post-marketing surveillance continues to monitor its long-term effects and safety profile.

Lab Monitoring

Renal function tests (especially in patients with pre-existing renal impairment or on prolonged high-dose therapy)
Liver function tests (rarely elevated, but monitored if concerns arise)
Complete blood count (CBC) if prolonged therapy is anticipated

Doctor Notes

Always inquire about the patient's history of hypersensitivity to beta-lactam antibiotics before prescribing.
Adjust dosage carefully in patients with renal impairment to avoid accumulation and potential toxicity.
Emphasize the importance of completing the entire course of therapy to prevent antibiotic resistance and ensure complete eradication of infection.
Advise patients to take with food for optimal absorption and to minimize gastrointestinal side effects.

Patient Guidelines

Complete the full course of medication as prescribed by your doctor, even if symptoms improve.
Do not stop taking the medicine early, as this may lead to recurrent infection or antibiotic resistance.
Take the tablet with food to reduce stomach upset and improve absorption.
Do not share this medicine with others.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

This medicine may cause dizziness or lightheadedness in some individuals. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.

Lifestyle Advice

Maintain good hydration by drinking plenty of fluids.
Ensure adequate rest to support recovery from infection.
Avoid alcohol consumption during the course of treatment, as it may exacerbate side effects.